PMID- 15389907
OWN - NLM
STAT- MEDLINE
DCOM- 20041109
LR  - 20071115
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 77
IP  - 2
DP  - 2004 Oct
TI  - Acute lymphoblastic leukemia with the phenotype of a putative B-cell/T-cell 
      bipotential precursor.
PG  - 156-60
AB  - Biphenotypic acute leukemias (BALs) are uncommon. Most are of myeloid-B-cell or 
      myeloid-T-cell lineage. We report herein a 70-year-old man with an unusual acute 
      leukemia where the blasts expressed both B- and T-lymphoid markers. He presented 
      to us with an enlarging cutaneous tumor. The presenting peripheral blood and bone 
      marrow aspirate showed 40% and 90% blasts, respectively, which were negative for 
      the usual cytochemical stains. The flow cytometric analysis revealed that the 
      blasts were positive for CD19, CD20, CD22, cytoplasmic (Cyt) CD79a, CD10, Cyt 
      CD3, CD5, CD7, CD4, HLA-DR, TdT, and were negative for myeloid markers. According 
      to the scoring system from the European Group for the Immunological 
      Characterization of Acute Leukaemias (EGIL), this case was an unequivocal 
      B-cell/T-cell BAL. Conventional cytogenetic analysis revealed 46XY 
      [t(4;11)(q31;q13), add(8)(q24), der(9)del(9)(p21)del(9)(q32q34), -13, +mar] in 
      all 25 metaphases analyzed. Fluorescence in situ hybridization (FISH) and 
      polymerase chain reaction (PCR) for 11q23 rearrangements as well as t(9;22) were 
      negative. PCR for both TCR-gamma and IgH gene analyses revealed polyclonal 
      rearrangements. We postulate that this case of BAL might have arisen from the 
      putative common lymphoid progenitor cell.
CI  - Copyright 2004 Wiley-Liss, Inc.
FAU - Lau, Lee Gong
AU  - Lau LG
AD  - Department of Hematology-Oncology, National University Hospital, Singapore. 
      LauLeeGong@nuh.com.sg
FAU - Tan, Lip Kun
AU  - Tan LK
FAU - Koay, Evelyn S C
AU  - Koay ES
FAU - Ee, Melvin H L
AU  - Ee MH
FAU - Tan, Suat Hoon
AU  - Tan SH
FAU - Liu, Te Chih
AU  - Liu TC
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Neoplasm)
SB  - IM
MH  - Aged
MH  - Antigens, CD/analysis
MH  - Antigens, Neoplasm/analysis
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Bone Marrow/pathology
MH  - Fatal Outcome
MH  - Flow Cytometry
MH  - Gene Rearrangement, beta-Chain T-Cell Antigen Receptor/genetics
MH  - Genes, Immunoglobulin/genetics
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Biphenotypic, Acute/*diagnosis/drug 
      therapy/genetics/immunology/pathology
MH  - *Leukemic Infiltration
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Skin/*pathology
EDAT- 2004/09/25 05:00
MHDA- 2004/11/13 09:00
CRDT- 2004/09/25 05:00
PHST- 2004/09/25 05:00 [pubmed]
PHST- 2004/11/13 09:00 [medline]
PHST- 2004/09/25 05:00 [entrez]
AID - 10.1002/ajh.20163 [doi]
PST - ppublish
SO  - Am J Hematol. 2004 Oct;77(2):156-60. doi: 10.1002/ajh.20163.