PMID- 15390165
OWN - NLM
STAT- MEDLINE
DCOM- 20050511
LR  - 20081121
IS  - 1050-9631 (Print)
IS  - 1050-9631 (Linking)
VI  - 15
IP  - 1
DP  - 2005
TI  - CREB phosphorylation and c-Fos expression in the hippocampus of rats during 
      acquisition and recall of a socially transmitted food preference.
PG  - 56-67
AB  - In the present study, phosphorylation of cAMP-response element binding protein 
      (pCREB) and expression of c-Fos were measured in the dorsal and ventral 
      hippocampus, as well as in a control region, the retrosplenial cortex, of rats 
      following acquisition and recall of a socially transmitted food preference 
      (STFP). Behavioral analyses revealed that STFP-trained rats showed a stronger 
      preference for the demonstrated food than did rats in social-control or 
      odor-control conditions. Rats in a social + odor control condition displayed an 
      intermediate preference that was not significantly different from either 
      STFP-trained rats or the social- or odor-controls. Immunocytochemical analyses 
      revealed increased pCREB-immunoreactivity (ir) in the ventral hippocampus of 
      STFP-trained rats in comparisons with rats in all three control conditions and 
      increased pCREB-ir in the dorsal hippocampus in comparisons with the social- and 
      odor-control conditions. In contrast, c-Fos-ir was greater in the dorsal 
      hippocampus of STFP-trained rats in comparisons with all three control conditions 
      and greater in the ventral hippocampus than rats in the social- and odor-control 
      conditions. Comparisons of pCREB-ir and c-Fos-ir were made also between 
      STFP-trained rats and social-controls following either acquisition or a 48-h 
      recall test. c-Fos-ir was greater in STFP-trained rats after both acquisition and 
      recall, whereas pCREB was greater after recall only. There were no differences in 
      either c-Fos-ir or pCREB-ir in comparisons between trained and control rats in 
      the retrosplenial cortex. The current results indicate that the activity of 
      transcription factors in the hippocampus is related to both acquisition and 
      retention of a socially transmitted food preference.
CI  - Copyright (c) 2004 Wiley-Liss, Inc.
FAU - Countryman, Renee A
AU  - Countryman RA
AD  - Department of Psychology, Tulane University, New Orleans, Louisiana 70118, USA.
FAU - Orlowski, Jessica D
AU  - Orlowski JD
FAU - Brightwell, Jennifer J
AU  - Brightwell JJ
FAU - Oskowitz, Adam Z
AU  - Oskowitz AZ
FAU - Colombo, Paul J
AU  - Colombo PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Cues
MH  - Cyclic AMP Response Element-Binding Protein/*metabolism
MH  - Feeding Behavior/*physiology
MH  - Hippocampus/anatomy & histology/*metabolism
MH  - Immunohistochemistry
MH  - Learning/*physiology
MH  - Male
MH  - Memory/*physiology
MH  - Neural Pathways/anatomy & histology/metabolism
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins c-fos/*metabolism
MH  - Rats
MH  - Rats, Long-Evans
MH  - Smell/physiology
MH  - Social Behavior
MH  - Transcriptional Activation/physiology
MH  - Up-Regulation/physiology
EDAT- 2004/09/25 05:00
MHDA- 2005/05/12 09:00
CRDT- 2004/09/25 05:00
PHST- 2004/09/25 05:00 [pubmed]
PHST- 2005/05/12 09:00 [medline]
PHST- 2004/09/25 05:00 [entrez]
AID - 10.1002/hipo.20030 [doi]
PST - ppublish
SO  - Hippocampus. 2005;15(1):56-67. doi: 10.1002/hipo.20030.