PMID- 15390187
OWN - NLM
STAT- MEDLINE
DCOM- 20050819
LR  - 20071114
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 41
IP  - 4
DP  - 2004 Dec
TI  - Analysis of translocations that involve the NUP98 gene in patients with 11p15 
      chromosomal rearrangements.
PG  - 339-52
AB  - The NUP98 gene has been reported to be fused with at least 15 partner genes in 
      leukemias with 11p15 translocations. We report the results of screening of cases 
      with cytogenetically documented rearrangements of 11p15 and the subsequent 
      identification of involvement of NUP98 and its partner genes. We identified 49 
      samples from 46 hematology patients with 11p15 (including a few with 11p14) 
      abnormalities, and using fluorescence in situ hybridization (FISH), we found that 
      NUP98 was disrupted in 7 cases. With the use of gene-specific FISH probes, in 6 
      cases, we identified the partner genes, which were PRRX1 (PMX1; in 2 cases), 
      HOXD13, RAP1GDS1, HOXC13, and TOP1. In the 3 cases for which RNA was available, 
      RT-PCR was performed, which confirmed the FISH results and identified the 
      location of the breakpoints in patient cDNA. Our data confirm the previous 
      findings that NUP98 is a recurrent target in various types of leukemia.
CI  - Copyright 2004 Wiley-Liss, Inc.
FAU - Kobzev, Yuri N
AU  - Kobzev YN
AD  - Section of Hematology/Oncology, Department of Medicine, Biological Sciences 
      Division, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.
FAU - Martinez-Climent, Jose
AU  - Martinez-Climent J
FAU - Lee, Sanggyu
AU  - Lee S
FAU - Chen, Jianjun
AU  - Chen J
FAU - Rowley, Janet D
AU  - Rowley JD
LA  - eng
GR  - CA-40046/CA/NCI NIH HHS/United States
GR  - CA-84405/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (HOXC13 protein, human)
RN  - 0 (HOXD13 protein, human)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Nuclear Pore Complex Proteins)
RN  - 0 (PRRX1 protein, human)
RN  - 0 (RAP1GDS1 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (nuclear pore complex protein 98)
RN  - EC 5.99.1.2 (DNA Topoisomerases, Type I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Base Sequence
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - DNA Topoisomerases, Type I/genetics
MH  - *Genetic Predisposition to Disease
MH  - Guanine Nucleotide Exchange Factors/genetics
MH  - Homeodomain Proteins/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Leukemia/*genetics
MH  - Male
MH  - Molecular Sequence Data
MH  - Nuclear Pore Complex Proteins/*genetics
MH  - Transcription Factors/genetics
MH  - *Translocation, Genetic
EDAT- 2004/09/25 05:00
MHDA- 2005/08/20 09:00
CRDT- 2004/09/25 05:00
PHST- 2004/09/25 05:00 [pubmed]
PHST- 2005/08/20 09:00 [medline]
PHST- 2004/09/25 05:00 [entrez]
AID - 10.1002/gcc.20092 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 2004 Dec;41(4):339-52. doi: 10.1002/gcc.20092.