PMID- 1541126
OWN - NLM
STAT- MEDLINE
DCOM- 19920408
LR  - 20190514
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 101
IP  - 3
DP  - 1992 Mar
TI  - Total circulating IgE and FEV1 in adult men. An epidemiologic longitudinal study.
PG  - 642-8
AB  - Epidemiologic data relating total circulating immunoglobulin E (IgE), an 
      objective marker of allergy, to cross-sectional and longitudinal FEV1 as well as 
      to methacholine bronchial hyperresponsiveness were obtained from 310 French adult 
      men surveyed five years apart. Skin prick test responses to common aeroallergens, 
      IgE level, and bronchial hyperresponsiveness were assessed at the end of the 
      follow-up. IgE level was not associated with PD20 to methacholine. 
      Cross-sectionally, age and height-adjusted FEV1 score was inversely related to 
      total IgE level (regression coefficient of FEV1 score on Log[IgE] beta = -.20; p 
      = 0.02). Stratified analysis showed that IgE level was associated with FEV1 score 
      only in nonsmokers (beta = -0.52; p less than 0.001), an association that 
      remained after exclusion of asthmatics. Longitudinally, five-year FEV1 decline 
      was related to IgE in nonsmokers (regression coefficient of FEV1 decline on 
      Log[IgE] beta = 19.9; p = 0.03) and exsmokers (beta = 18.9; p = 0.06) but not in 
      current smokers. The relationship persisted, even if with lesser significance, 
      among exsmokers after exclusion of asthmatics (beta = 17.2) and further exclusion 
      of skin prick test-positive men (beta = 18.8). Whether IgE production also 
      reflects factors other than allergy, possibly nonallergic inflammation, needs 
      further investigations.
FAU - Annesi, I
AU  - Annesi I
AD  - Institut National de la Sante et de la Recherche Medicale, Epidemiological 
      Research Unit Villejuif, France.
FAU - Oryszczyn, M P
AU  - Oryszczyn MP
FAU - Frette, C
AU  - Frette C
FAU - Neukirch, F
AU  - Neukirch F
FAU - Orvoen-Frija, E
AU  - Orvoen-Frija E
FAU - Kauffmann, F
AU  - Kauffmann F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Chest. 1992 Mar;101(3):596-7. PMID: 1541115
CIN - Chest. 1993 Aug;104(2):649-50. PMID: 8339677
MH  - Adult
MH  - Asthma/epidemiology/etiology/immunology/physiopathology
MH  - Bronchial Provocation Tests
MH  - Cross-Sectional Studies
MH  - *Forced Expiratory Volume
MH  - Humans
MH  - Hypersensitivity, Immediate/diagnosis
MH  - Immunoglobulin E/*analysis
MH  - Longitudinal Studies
MH  - Male
MH  - Methacholine Chloride
MH  - Middle Aged
MH  - Risk Factors
MH  - Skin Tests
MH  - Smoking/adverse effects
EDAT- 1992/03/01 00:00
MHDA- 1992/03/01 00:01
CRDT- 1992/03/01 00:00
PHST- 1992/03/01 00:00 [pubmed]
PHST- 1992/03/01 00:01 [medline]
PHST- 1992/03/01 00:00 [entrez]
AID - S0012-3692(16)31934-1 [pii]
AID - 10.1378/chest.101.3.642 [doi]
PST - ppublish
SO  - Chest. 1992 Mar;101(3):642-8. doi: 10.1378/chest.101.3.642.