PMID- 15454664
OWN - NLM
STAT- MEDLINE
DCOM- 20041229
LR  - 20191026
IS  - 1543-1894 (Print)
IS  - 1543-1894 (Linking)
VI  - 104
DP  - 2005
TI  - Mutant animal models of stroke and gene expression: the stroke-prone 
      spontaneously hypertensive rat.
PG  - 49-74
AB  - The recent completion of the Human Genome Project provides the potential to 
      advance our knowledge of pathogenesis and identify the gene(s) associated with 
      particular diseases. However, using human DNA to correlate individual genomic 
      variations with particular disorders such as stroke will be extremely challenging 
      because of the large number of variables within an individual, and across 
      different populations. Mutant animal models of stroke such as the stroke-prone 
      spontaneously hypertensive rat (SHRSP) provide the scientist with genetic 
      homogeneity, not possible within a human population, to aid our search for 
      causative genes. This chapter describes the methods our group have employed to 
      study the genetic heritability of stroke sensitivity in the SHRSP. Sections are 
      included on quantitative trait loci, mapping, and congenic strain construction 
      for the identification of genetic determinants of stroke sensitivity in the 
      SHRSP.
FAU - Carswell, Hilary V O
AU  - Carswell HV
AD  - Division of Clinical Neuroscience, Wellcome Surgical Institute, University of 
      Glasgow, Scotland, University Kingdom.
FAU - McBride, Martin W
AU  - McBride MW
FAU - Graham, Delyth
AU  - Graham D
FAU - Dominiczak, Anna F
AU  - Dominiczak AF
FAU - Macrae, I Mhairi
AU  - Macrae IM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Med
JT  - Methods in molecular medicine
JID - 101123138
SB  - IM
MH  - Animals
MH  - Crosses, Genetic
MH  - Disease Models, Animal
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Infarction, Middle Cerebral Artery/etiology/genetics/pathology
MH  - Male
MH  - Microsatellite Repeats
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - Quantitative Trait Loci
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Rats, Mutant Strains
MH  - Stroke/etiology/*genetics/pathology
EDAT- 2004/09/30 05:00
MHDA- 2004/12/30 09:00
CRDT- 2004/09/30 05:00
PHST- 2004/09/30 05:00 [pubmed]
PHST- 2004/12/30 09:00 [medline]
PHST- 2004/09/30 05:00 [entrez]
AID - 1-59259-836-6:049 [pii]
AID - 10.1385/1-59259-836-6:049 [doi]
PST - ppublish
SO  - Methods Mol Med. 2005;104:49-74. doi: 10.1385/1-59259-836-6:049.