PMID- 15456837
OWN - NLM
STAT- MEDLINE
DCOM- 20050318
LR  - 20171116
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 312
IP  - 2
DP  - 2005 Feb
TI  - Evidence for the involvement of nitric oxide in 
      3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain.
PG  - 694-701
AB  - Production of reactive oxygen and/or nitrogen species has been thought to 
      contribute to the long-term depletion of brain dopamine and serotonin (5-HT) 
      produced by amphetamine derivatives, i.e., methamphetamine and 
      3,4-methylenedioxymethamphetamine (MDMA). In the present study, the effects of 
      nitric-oxide synthase (NOS) inhibitors were examined on the long-term depletion 
      of striatal dopamine and/or 5-HT produced by the local perfusion of malonate and 
      MDMA or the systemic administration of MDMA. The effect of MDMA on nitric oxide 
      formation and nitrotyrosine concentration also was determined. Perfusion with 
      MDMA and malonate resulted in a 34% reduction of 5-HT and 49% reduction of 
      dopamine concentrations in the striatum. The systemic administration of NOS 
      inhibitors, N(omega)-nitro-l-arginine methyl ester hydrochloride and 
      S-methyl-l-thiocitrulline (S-MTC), and the peroxynitrite decomposition catalyst 
      Fe(III) tetrakis (1-methyl-4-pyridyl) porphyrin pentachloride attenuated the 
      MDMA- and malonate-induced depletion of striatal dopamine and 5-HT. S-MTC also 
      attenuated the depletion of 5-HT in the striatum produced by the systemic 
      administration of MDMA without attenuating MDMA-induced hyperthermia. 
      Additionally, the systemic administration of MDMA significantly increased the 
      formation of nitric oxide and the nitrotyrosine concentration in the striatum. 
      These results support the conclusion that MDMA produces reactive nitrogen species 
      in the rat that contribute to the neurotoxicity of this amphetamine analog.
FAU - Darvesh, Altaf S
AU  - Darvesh AS
AD  - University of Cincinnati, College of Pharmacy, 3223 Eden Ave., Cincinnati, OH 
      45267, USA.
FAU - Yamamoto, Bryan K
AU  - Yamamoto BK
FAU - Gudelsky, Gary A
AU  - Gudelsky GA
LA  - eng
GR  - DA07427/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20040929
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Malonates)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Serotonin Agents)
RN  - 14691-52-2 (Peroxynitrous Acid)
RN  - 29VT07BGDA (Citrulline)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 333DO1RDJY (Serotonin)
RN  - 3604-79-3 (3-nitrotyrosine)
RN  - 42HK56048U (Tyrosine)
RN  - 9KX7ZMG0MK (malonic acid)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type I)
RN  - EC 1.14.13.39 (Nos1 protein, rat)
RN  - GYV9AM2QAG (Thiourea)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - M790X706JV (S-methylthiocitrulline)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain Chemistry/*drug effects
MH  - Citrulline/*analogs & derivatives/pharmacology
MH  - Dopamine/metabolism
MH  - Enzyme Inhibitors/pharmacology
MH  - Fever/chemically induced/physiopathology
MH  - Male
MH  - Malonates/pharmacology
MH  - Microdialysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Neostriatum/drug effects/metabolism
MH  - Nerve Tissue Proteins/antagonists & inhibitors
MH  - Nitric Oxide/*physiology
MH  - Nitric Oxide Synthase/antagonists & inhibitors
MH  - Nitric Oxide Synthase Type I
MH  - Peroxynitrous Acid/pharmacology
MH  - Rats
MH  - Serotonin/*metabolism
MH  - Serotonin Agents/*pharmacology
MH  - Thiourea/*analogs & derivatives/pharmacology
MH  - Tyrosine/*analogs & derivatives/metabolism
EDAT- 2004/10/01 05:00
MHDA- 2005/03/19 09:00
CRDT- 2004/10/01 05:00
PHST- 2004/10/01 05:00 [pubmed]
PHST- 2005/03/19 09:00 [medline]
PHST- 2004/10/01 05:00 [entrez]
AID - jpet.104.074849 [pii]
AID - 10.1124/jpet.104.074849 [doi]
PST - ppublish
SO  - J Pharmacol Exp Ther. 2005 Feb;312(2):694-701. doi: 10.1124/jpet.104.074849. Epub 
      2004 Sep 29.