PMID- 15456923
OWN - NLM
STAT- MEDLINE
DCOM- 20050316
LR  - 20100917
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 82
IP  - 2
DP  - 2004 Dec
TI  - Recovery from welding-fume-exposure-induced lung fibrosis and pulmonary function 
      changes in sprague dawley rats.
PG  - 608-13
AB  - Welder's pneumoconiosis has generally been determined as benign based on the 
      absence of pulmonary function abnormalities in welders with marked radiographic 
      abnormalities. Yet, there have also been several reports on welders with 
      respiratory symptoms, indicating lung function impairment, X-ray abnormalities, 
      and extensive fibrosis. Accordingly, this study attempted to investigate the 
      inflammatory responses and pulmonary function changes in rats during a 60-day 
      welding-fume-inhalation exposure period to elucidate the process of fibrosis. The 
      rats were exposed to manual metal-arc stainless-steel welding fumes (MMA-SS) with 
      total suspended particulate concentrations of 64.8 +/- 0.9 (low dose) and 107.8 
      +/- 2.6 mg/m3 (high dose) for 2 h per day in an inhalation chamber for 60 days. 
      Animals were sacrificed after the initial 2-h exposure and after 15, 30, and 60 
      days, and the pulmonary function was also measured every week after the daily 
      exposure. Elevated cellular differential counts were also measured in the 
      acellular bronchoalveolar lavage fluid of the rats exposed to the MMA-SS fumes 
      for 60 days. Among the pulmonary function test parameters, only the tidal volume 
      showed a statistically significant and dose-dependent decrease after 35 to 60 
      days of MMA-SS welding-fume exposure. When the rats exposed to the welding fumes 
      were left for 60 days to recover their lung function and cellular 
      differentiation, recovery was observed in both the high and low-dose rats exposed 
      up to 30 days, resulting in the disappearance of inflammatory cells and 
      restoration of the tidal volume. The rats exposed for 60 days at the low dose 
      also recovered from the inflammation and tidal volume loss, yet the rats exposed 
      for 60 days at the high dose did not fully recover even after a 60-day recovery 
      period. Therefore, when taken together, the results of the current study suggest 
      that a decrease in the tidal volume could be used as an early indicator of 
      pulmonary fibrosis induced by welding-fume exposure in Sprague Dawley rats, and 
      fibrosis would seem to be preventable if the exposure is short-term and moderate.
FAU - Sung, Jae Hyuck
AU  - Sung JH
AD  - Center for Occupational Toxicology, Occupational Safety & Health Research 
      Institute, Daejeon, 305-380, Korea.
FAU - Choi, Byung-Gil
AU  - Choi BG
FAU - Maeng, Seung-Hee
AU  - Maeng SH
FAU - Kim, Soo-Jin
AU  - Kim SJ
FAU - Chung, Yong Hyun
AU  - Chung YH
FAU - Han, Jeong Hee
AU  - Han JH
FAU - Song, Kyung Seuk
AU  - Song KS
FAU - Lee, Yong Hwan
AU  - Lee YH
FAU - Cho, Yong Bong
AU  - Cho YB
FAU - Cho, Myung-Haing
AU  - Cho MH
FAU - Kim, Kwang Jong
AU  - Kim KJ
FAU - Hyun, Jin Suk
AU  - Hyun JS
FAU - Yu, Il Je
AU  - Yu IJ
LA  - eng
PT  - Journal Article
DEP - 20040929
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Bronchoalveolar Lavage Fluid
MH  - *Inhalation Exposure
MH  - Male
MH  - Pneumoconiosis/pathology
MH  - Pulmonary Fibrosis/*chemically induced/pathology/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Respiratory Function Tests
MH  - Tidal Volume/drug effects
MH  - *Welding
EDAT- 2004/10/01 05:00
MHDA- 2005/03/17 09:00
CRDT- 2004/10/01 05:00
PHST- 2004/10/01 05:00 [pubmed]
PHST- 2005/03/17 09:00 [medline]
PHST- 2004/10/01 05:00 [entrez]
AID - kfh289 [pii]
AID - 10.1093/toxsci/kfh289 [doi]
PST - ppublish
SO  - Toxicol Sci. 2004 Dec;82(2):608-13. doi: 10.1093/toxsci/kfh289. Epub 2004 Sep 29.