PMID- 15458431
OWN - NLM
STAT- MEDLINE
DCOM- 20050225
LR  - 20220330
IS  - 0085-2538 (Print)
IS  - 0085-2538 (Linking)
VI  - 66
IP  - 4
DP  - 2004 Oct
TI  - Urinary excretion of aquaporin-2 water channel exaggerated dependent upon 
      vasopressin in congestive heart failure.
PG  - 1387-92
AB  - BACKGROUND: Impaired water excretion occurs in patients with congestive heart 
      failure. The present study was undertaken to determine whether urinary excretion 
      of aquaporin-2 (AQP-2) water channel is exaggerated in patients with congestive 
      heart failure dependent upon arginine vasopressin (AVP). METHODS: Sixty-five 
      patients with congestive heart failure and eight age- and gender-matched control 
      subjects were examined. The patients were divided into four groups according to 
      the criteria of New York Heart Association (NYHA). Plasma AVP levels, urinary 
      excretion of AQP-2, and cardiac index were determined. RESULTS: Plasma AVP levels 
      were progressively increased following the severity of NYHA class in the patients 
      with congestive heart failure. Cardiac index was inversely decreased, and there 
      was a negative correlation between plasma AVP levels and cardiac index (r=-0.430, 
      P < 0.02). Urinary excretion of AQP-2 was 187.3 +/- 50.2 fmol/mg creatinine in 
      the control subjects. It was markedly increased in the patients. Urinary 
      excretion of AQP-2 was elevated to 1144.4 +/- 257.5 and 990.5 +/- 176.0 fmol/mg 
      creatinine in the patients with NYHA class III and class IV, respectively, values 
      significantly greater than the control subjects (P < 0.05). Urinary excretion of 
      AQP-2 had a positive correlation with plasma AVP levels (r= 0.280, P < 0.02). 
      CONCLUSION: The present study indicates that exaggerated urinary excretion of 
      AQP-2 is dependent on baroreceptor-mediated release of AVP in patients with 
      congestive heart failure.
FAU - Funayama, Hiroshi
AU  - Funayama H
AD  - Department of Medicine, Jichi Medical School, Omiya Medical Center, Saitama, 
      Japan.
FAU - Nakamura, Tomohiro
AU  - Nakamura T
FAU - Saito, Takako
AU  - Saito T
FAU - Yoshimura, Akio
AU  - Yoshimura A
FAU - Saito, Muneyasu
AU  - Saito M
FAU - Kawakami, Masanobu
AU  - Kawakami M
FAU - Ishikawa, San-E
AU  - Ishikawa SE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (AQP2 protein, human)
RN  - 0 (Aquaporin 2)
RN  - 0 (Aquaporins)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aquaporin 2
MH  - Aquaporins/*urine
MH  - Arginine Vasopressin/*blood
MH  - Female
MH  - Heart Failure/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osmolar Concentration
MH  - Pressoreceptors/physiology
MH  - Sodium/blood
EDAT- 2004/10/02 05:00
MHDA- 2005/02/26 09:00
CRDT- 2004/10/02 05:00
PHST- 2004/10/02 05:00 [pubmed]
PHST- 2005/02/26 09:00 [medline]
PHST- 2004/10/02 05:00 [entrez]
AID - S0085-2538(15)50205-6 [pii]
AID - 10.1111/j.1523-1755.2004.00902.x [doi]
PST - ppublish
SO  - Kidney Int. 2004 Oct;66(4):1387-92. doi: 10.1111/j.1523-1755.2004.00902.x.