PMID- 15458747
OWN - NLM
STAT- MEDLINE
DCOM- 20050310
LR  - 20231213
IS  - 1071-5576 (Print)
IS  - 1071-5576 (Linking)
VI  - 11
IP  - 7
DP  - 2004 Oct
TI  - Antigen-presenting cells in human endometrium during the menstrual cycle compared 
      to early pregnancy.
PG  - 488-93
AB  - OBJECTIVE: Human endometrium and early pregnancy decidua harbor a considerable 
      and diverse population of antigen-presenting cells (APC). Changes in the number 
      and distribution of macrophages and dendritic cells (DC) could point to a 
      possible role of these immunocompetent cells in implantation and success of early 
      pregnancy. METHODS: Uterine tissue was obtained from 22 women undergoing 
      hysterectomy for bleeding disorders or dysmenorrhea and from 11 women undergoing 
      legal abortion. Tissue was investigated with antibodies against CD14, CD68, CD83, 
      DC-SIGN, Ki-67, and human leukocyte antigen (HLA)-DR using single and double 
      immunohistochemical staining techniques. RESULTS: The number of CD14(+) cells was 
      stable during all phases of the menstrual cycle and early pregnancy. In 
      comparison to nonpregnant endometrium, DC-SIGN(+) cells showed a higher 
      proliferation rate and were found associated in clusters with CD56(+) natural 
      killer (NK) cells in early pregnancy. In the late secretory phase of the 
      menstrual cycle, numbers of CD83(+) (P <.01) cells were significantly higher than 
      in other endometrial phases and early pregnancy. HLA-DR(+) expression was 
      significantly increased in early pregnancy but remained unchanged throughout the 
      menstrual cycle. CONCLUSION: The presence of DC-SIGN(+) cells during the 
      menstrual cycle and their proliferation in early pregnancy suggests an important 
      role of these cells with regard to the balance between defense against pathogens 
      and tolerance of the fetal allograft. Whether the increase of CD83(+) mature DC 
      and CD68(+) macrophages in the late secretory phase is caused by hormonal stimuli 
      and/or is due to changes of the cytokine/chemokine micromilieu remains to be 
      investigated.
FAU - Rieger, L
AU  - Rieger L
AD  - Department of Obstetrics and Gynecology, University of Wurzburg, Wurzburg, 
      Germany.
FAU - Honig, A
AU  - Honig A
FAU - Sutterlin, M
AU  - Sutterlin M
FAU - Kapp, M
AU  - Kapp M
FAU - Dietl, J
AU  - Dietl J
FAU - Ruck, P
AU  - Ruck P
FAU - Kammerer, U
AU  - Kammerer U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Soc Gynecol Investig
JT  - Journal of the Society for Gynecologic Investigation
JID - 9433806
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (CD68 antigen, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Immunoglobulins)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Abortion, Induced
MH  - Antigen-Presenting Cells/*cytology/immunology
MH  - Antigens, CD/analysis
MH  - Antigens, Differentiation, Myelomonocytic/analysis
MH  - Cell Adhesion Molecules/analysis
MH  - Cell Count
MH  - Cell Division
MH  - Endometrium/*cytology
MH  - Female
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Hysterectomy
MH  - Immunoglobulins/analysis
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - Ki-67 Antigen/analysis
MH  - Lectins, C-Type/analysis
MH  - Lipopolysaccharide Receptors/analysis
MH  - Membrane Glycoproteins/analysis
MH  - *Menstrual Cycle
MH  - Pregnancy
MH  - Receptors, Cell Surface/analysis
MH  - CD83 Antigen
EDAT- 2004/10/02 05:00
MHDA- 2005/03/11 09:00
CRDT- 2004/10/02 05:00
PHST- 2004/10/02 05:00 [pubmed]
PHST- 2005/03/11 09:00 [medline]
PHST- 2004/10/02 05:00 [entrez]
AID - S1071-5576(04)00187-X [pii]
AID - 10.1016/j.jsgi.2004.05.007 [doi]
PST - ppublish
SO  - J Soc Gynecol Investig. 2004 Oct;11(7):488-93. doi: 10.1016/j.jsgi.2004.05.007.