PMID- 15459244
OWN - NLM
STAT- MEDLINE
DCOM- 20050406
LR  - 20220309
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 561
IP  - Pt 1
DP  - 2004 Nov 15
TI  - Interhemispheric interaction between human dorsal premotor and contralateral 
      primary motor cortex.
PG  - 331-8
AB  - We used transcranial magnetic stimulation (TMS) in a paired pulse protocol to 
      investigate interhemispheric interactions between the right dorsal premotor (dPM) 
      and left primary motor cortex (M1) using interstimulus intervals of 4, 6, 8, 10, 
      12, 16 and 20 ms in ten healthy subjects. A conditioning stimulus over right dPM 
      at an intensity of either 90 or 110% resting motor threshold (RMT) suppressed 
      motor-evoked potentials (MEPs) evoked in the first dorsal interosseous (FDI) 
      muscle by stimulation of left M1. Maximum effects occurred for interstimulus 
      intervals (ISIs) of 8-10 ms. There was no effect if the conditioning stimulus was 
      applied 2.5 cm lateral, anterior or medial to dPM. The effect differed from 
      previously described M1 interhemispheric inhibition in that the threshold for the 
      latter was greater than 90% RMT, whereas stimulation of the dPM at the same 
      intensity led to significant inhibition. In addition, voluntary contraction of 
      the left FDI (i.e. contralateral to the conditioning TMS) enhanced 
      interhemispheric inhibition from right M1 but had no effect on the inhibition 
      from right dPM. Finally, conditioning to right dPM at 90% RMT reduced 
      short-interval intracortical inhibition (SICI; at ISI = 2 ms) in left M1 whilst 
      there was no effect if the conditioning stimulus was applied to right M1. We 
      conclude that conditioning TMS over dPM has effects that differ from the previous 
      pattern of interhemispheric inhibition described between bilateral M1s. This may 
      reflect the existence of commissural fibres between dPM and contralateral M1 that 
      may play a role in bimanual coordination.
FAU - Mochizuki, Hitoshi
AU  - Mochizuki H
AD  - Sobell Department of Motor Neuroscience and Movement Disorders, Institute of 
      Neurology, University College London, London WC1N 3BG, UK.
FAU - Huang, Ying-Zu
AU  - Huang YZ
FAU - Rothwell, John C
AU  - Rothwell JC
LA  - eng
PT  - Journal Article
DEP - 20040930
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Electric Stimulation
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Functional Laterality/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiology
MH  - Neural Inhibition/physiology
MH  - Volition/physiology
PMC - PMC1665328
EDAT- 2004/10/02 05:00
MHDA- 2005/04/07 09:00
PMCR- 2005/11/15
CRDT- 2004/10/02 05:00
PHST- 2004/10/02 05:00 [pubmed]
PHST- 2005/04/07 09:00 [medline]
PHST- 2004/10/02 05:00 [entrez]
PHST- 2005/11/15 00:00 [pmc-release]
AID - jphysiol.2004.072843 [pii]
AID - 10.1113/jphysiol.2004.072843 [doi]
PST - ppublish
SO  - J Physiol. 2004 Nov 15;561(Pt 1):331-8. doi: 10.1113/jphysiol.2004.072843. Epub 
      2004 Sep 30.