PMID- 15460403
OWN - NLM
STAT- MEDLINE
DCOM- 20050322
LR  - 20061115
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 35
IP  - 5
DP  - 2004 Sep
TI  - [Dendritic cells, natural killer cells and adhesion molecules in psoriasis].
PG  - 626-9
AB  - OBJECTIVE: To study the role of the dendritic cells, natural killer cells and 
      adhesion molecules play in the pathogenesis of psoriasis. METHODS: The expression 
      levels of human leukocyte antigen (HLA)-DR, CD1a, CD16, CD57, tumor necrosis 
      factor (TNF)-alpha and intercellular adhesion molecule (ICAM)-1 were detected by 
      immunohistochemistry in lesions of 26 patients with psoriasis before and after 
      treatment. RESULTS: The expression of HLA-DR, CD1a, CD16, CD57, TNF-alpha and 
      ICAM-1 showed no significant difference between the active phase and the static 
      phase of psoriatic lesions (P>0.05). After treatment, the positive expression of 
      all markers decreased evidently or even disappeared with histopathological 
      improvement in the resolvent phase of psoriatic lesions. There were statistically 
      significant difference by Wilcoxon rank sum test (P<0.05). CONCLUSION: Dendritic 
      cells, natural killer cells and adhesion molecules play an important role in the 
      pathogenesis of psoriasis.
FAU - Zhang, Min
AU  - Zhang M
AD  - Department of Dermatology, West China Hospital, Sichuan University, Chengdu 
      610041, China.
FAU - Zhang, Yi-zhi
AU  - Zhang YZ
FAU - Wang, Sheng
AU  - Wang S
FAU - Wang, Lin
AU  - Wang L
FAU - Li, Feng-yuan
AU  - Li FY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (HLA-DR Antigens)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Adult
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - HLA-DR Antigens/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Intercellular Adhesion Molecule-1/*metabolism
MH  - Killer Cells, Natural/*immunology
MH  - Male
MH  - Psoriasis/etiology/*immunology/metabolism
MH  - Skin/immunology/pathology
EDAT- 2004/10/06 09:00
MHDA- 2005/03/23 09:00
CRDT- 2004/10/06 09:00
PHST- 2004/10/06 09:00 [pubmed]
PHST- 2005/03/23 09:00 [medline]
PHST- 2004/10/06 09:00 [entrez]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Sep;35(5):626-9.