PMID- 15460405
OWN - NLM
STAT- MEDLINE
DCOM- 20050322
LR  - 20071115
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 35
IP  - 5
DP  - 2004 Sep
TI  - [Expression of MCP-1 in airway of rats with COPD].
PG  - 634-7
AB  - OBJECTIVE: To explore the role of monocyte chemoattractant protein-1 (MCP-1) in 
      the pathogenesis of chronic obstructive plumonary disease (COPD). METHODS: Rat 
      COPD model was established by exposing the rats to cigarette smoke daily. After 
      COPD model was set up, bronchoalveolar lavage was performed. Total cell counts 
      and alveolar macrophage (AM) counts in bronchoalveolar lavage fluid (BALF) were 
      examined and the levels of MCP-1 and tumor necrosis factor-alpha (TNF-alpha) in 
      BALF and serum were measured by ELISA. Lung tissue sections stained by HE were 
      measured in terms of MLI, MAN and PAA by picture analysis system. RESULTS: MLI 
      and PAA in COPD model were higher than those of control group while MAN was just 
      on the contrary. Except MCP-1 levels in serum [(32.75 +/- 10.91) pg/ml vs (24.13 
      +/- 6.92) pg/ml, P>0.05], MCP-1 levels, TNF-alpha levels, total cell counts and 
      AM counts in BALF of COPD model group were significantly higher than those of 
      control group (P<0.01). Positive correlations were demonstrated among MCP-1 
      levels, TNF-alpha levels and AM counts in BALF in COPD group, but were not 
      demonstrated between MCP-1 levels, TNF-alpha levels in serum and AM counts. 
      CONCLUSION: There is a close correlation between MCP-1 in BALF and airway 
      inflammation in COPD.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Respiratory Medicine, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Cheng, De-yun
AU  - Cheng DY
FAU - Guan, Jian
AU  - Guan J
FAU - Chen, Xiao-ju
AU  - Chen XJ
FAU - Zhang, Yong
AU  - Zhang Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Chemokine CCL4)
RN  - 0 (Macrophage Inflammatory Proteins)
SB  - IM
MH  - Animals
MH  - Bronchitis, Chronic/metabolism/physiopathology
MH  - Bronchoalveolar Lavage Fluid/cytology
MH  - Chemokine CCL4
MH  - Lung/*metabolism
MH  - Macrophage Inflammatory Proteins/analysis/*metabolism
MH  - Macrophages, Alveolar/drug effects/metabolism
MH  - Male
MH  - Pulmonary Disease, Chronic Obstructive/etiology/*metabolism/physiopathology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
EDAT- 2004/10/06 09:00
MHDA- 2005/03/23 09:00
CRDT- 2004/10/06 09:00
PHST- 2004/10/06 09:00 [pubmed]
PHST- 2005/03/23 09:00 [medline]
PHST- 2004/10/06 09:00 [entrez]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Sep;35(5):634-7.