PMID- 15461094
OWN - NLM
STAT- MEDLINE
DCOM- 20050124
LR  - 20101118
IS  - 0022-1198 (Print)
IS  - 0022-1198 (Linking)
VI  - 49
IP  - 5
DP  - 2004 Sep
TI  - Enhanced kinship analysis and STR-based DNA typing for human identification in 
      mass fatality incidents: the Swissair flight 111 disaster.
PG  - 939-53
AB  - A bioinformatic tool was developed to assist with the victim identification 
      initiative that followed the Swissair Flight 111 disaster. Making use of short 
      tandem repeat (STR) DNA typing data generated with AmpFlSTR Profiler Plus (PP) 
      and AmpFlSTR COfiler(CO) kits, the software systematically compared each 
      available STR genotype with every other genotype. The matching algorithm was 
      based on the search for: (i) direct matches to genotypes derived from personal 
      effects; and (ii) potential kinship associations between victims and next-of-kin, 
      as measured by allele sharing at individual loci. The software greatly assisted 
      parentage analysis by enabling kinship evaluation in situations where complete 
      parentage trios were unavailable and, in some situations, with distantly related 
      relatives. Exclusion of fortuitous kinship associations (FKA) was made possible 
      through the recovery at the disaster site of at least one remains for every 
      sought-after victim, and was incorporated into the kinship software. The data 
      from the 13 combined STR loci produced 6 and 23 times fewer FKAs when compared 
      with PP alone and AmpFlSTR Profiler (PR) alone, respectively. Identification 
      leads or confirmations of identification were obtained for 218 victims for which 
      DNA reference samples (personal effects and kin) had been submitted. Confirmation 
      of an inferred kinship association was sought through frequency and likelihood 
      calculations, as well as corroborative data from other identification modalities. 
      The use of a simple, yet powerful, automated genotype comparison approach and the 
      use of megaplexes with high power of discrimination (PD) values extended 
      considerably the identification capabilities in the case of the Swissair 
      disaster. The DNA typing identification modality proved to be a valuable 
      component of the large arsenal of identification tools deployed in the aftermath 
      of this disaster.
FAU - Leclair, Benoit
AU  - Leclair B
AD  - National DNA Data Bank, Royal Canadian Mounted Police, 1200 Vanier Parkway, 
      Ottawa, Ontario, Canada, K1G 3M8.
FAU - Fregeau, Chantal J
AU  - Fregeau CJ
FAU - Bowen, Kathy L
AU  - Bowen KL
FAU - Fourney, Ron M
AU  - Fourney RM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
SB  - IM
MH  - *Accidents, Aviation
MH  - Algorithms
MH  - Alleles
MH  - DNA Fingerprinting/*methods
MH  - Female
MH  - Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Likelihood Functions
MH  - Male
MH  - Mutation
MH  - Pedigree
MH  - Polymerase Chain Reaction
MH  - Sex Determination Processes
MH  - Software
MH  - *Tandem Repeat Sequences
EDAT- 2004/10/06 09:00
MHDA- 2005/01/26 09:00
CRDT- 2004/10/06 09:00
PHST- 2004/10/06 09:00 [pubmed]
PHST- 2005/01/26 09:00 [medline]
PHST- 2004/10/06 09:00 [entrez]
PST - ppublish
SO  - J Forensic Sci. 2004 Sep;49(5):939-53.