PMID- 15461600
OWN - NLM
STAT- MEDLINE
DCOM- 20050419
LR  - 20110621
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 59
IP  - 11
DP  - 2004 Nov
TI  - Allergy to jackfruit: a novel example of Bet v 1-related food allergy.
PG  - 1187-92
AB  - BACKGROUND: Jackfruit allergy has been reported just once. It is unknown whether 
      this food allergy is caused by direct sensitization or cross-sensitization to 
      pollen allergens. OBJECTIVE: Establish whether jackfruit allergy is linked to 
      birchpollen allergy. METHODS: Two jackfruit allergic patients and five patients 
      with birchpollen-related apple allergy were recruited. Sensitization to pollen 
      and plant foods was assessed by skin prick test (SPT), radio-allergosorbent test 
      (RAST) and immunoblot. RAST analysis was performed for Bet v 1 and Mal d 1. 
      Cross-reactivity was evaluated by RAST and immunoblot-inhibition. Biological 
      activity of immunoglobulin E (IgE) was measured by basophil histamine release. 
      Allergy to jackfruit was evaluated by double-blind placebo-controlled food 
      challenge (DBPCFC) or open challenge (OC). RESULTS: In both patients DBPCFC 
      confirmed the reported jackfruit allergy. SPT was 41 and 27 mm2 and specific IgE 
      to jackfruit was 5.9 and 0.8 IU/ml, respectively. Immunoblot analysis revealed 
      IgE reactivity at Mr of approximately 17 kDa. The Bet v 1-related nature of this 
      allergen in jackfruit was demonstrated by RAST and immunoblot inhibition. To 
      assess whether jackfruit allergy might be common in patients with combined 
      birchpollen-fruit allergy, five such patients underwent an OC with jackfruit. All 
      five had OA-like symptoms. CONCLUSIONS: Jackfruit allergy can be added to the 
      list of birchpollen-related food allergies. Increased consumption of this fruit 
      will result in a rise in allergic reactions.
CI  - Copyright 2004 Blackwell Munksgaard
FAU - Bolhaar, S T H P
AU  - Bolhaar ST
AD  - Department Allergology/Dermatology, University Medical Center Utrecht, Utrecht, 
      The Netherlands.
FAU - Ree, R
AU  - Ree R
FAU - Bruijnzeel-Koomen, C A F M
AU  - Bruijnzeel-Koomen CA
FAU - Knulst, A C
AU  - Knulst AC
FAU - Zuidmeer, L
AU  - Zuidmeer L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 0 (Plant Proteins)
RN  - 126161-14-6 (Bet v 1 allergen, Betula)
SB  - IM
MH  - Adult
MH  - Allergens/*immunology
MH  - Antigens, Plant
MH  - Artocarpus/*immunology
MH  - Betula/immunology
MH  - Cross Reactions/immunology
MH  - Double-Blind Method
MH  - Female
MH  - Food Hypersensitivity/complications/*diagnosis/immunology
MH  - Humans
MH  - Male
MH  - Malus/immunology
MH  - Plant Proteins/*immunology
MH  - Pollen/*immunology
MH  - Rhinitis, Allergic, Seasonal/complications/immunology
EDAT- 2004/10/06 09:00
MHDA- 2005/04/20 09:00
CRDT- 2004/10/06 09:00
PHST- 2004/10/06 09:00 [pubmed]
PHST- 2005/04/20 09:00 [medline]
PHST- 2004/10/06 09:00 [entrez]
AID - ALL544 [pii]
AID - 10.1111/j.1398-9995.2004.00544.x [doi]
PST - ppublish
SO  - Allergy. 2004 Nov;59(11):1187-92. doi: 10.1111/j.1398-9995.2004.00544.x.