PMID- 15462603
OWN - NLM
STAT- MEDLINE
DCOM- 20041110
LR  - 20190922
IS  - 0025-8105 (Print)
IS  - 0025-8105 (Linking)
VI  - 57
IP  - 3-4
DP  - 2004 Mar-Apr
TI  - [Heredity of psoriasis].
PG  - 171-4
AB  - INTRODUCTION: Epidemiological studies of twins show that there is a genetic 
      predisposition to psoriasis. Researches conducted so far show that psoriasis is a 
      multifactorial polygenetic disease with reduced gene penetration. They also show 
      that heredity is more significant than the "trigger" factor whose influence is 
      limited to the exchange of phenotypes. Researches in USA, Canada and Europe 
      identified four most important loci (psoriasis susceptibility--1-4). At least one 
      is in MHC (major histocompatibility complex) due to the connection between 
      psoriasis and alleles of human leukocyte antigen (HLA). OBJECTIVE: Our study 
      included 117 patients and examined the indicators of genetic predisposition to 
      psoriasis: frequency of psoriasis among relatives of psoriatic probands; 
      frequency of psoriasis among relatives (I and II degree) of psoriatic patients; 
      age of probands and other relatives at the onset of illness. MATERIAL AND 
      METHODS: We have used a structured questionnaire for collection of data about 
      existence of psoriasis in relatives of I and II degree of psoriatic probands and 
      about the age of probands and relatives at the time of onset. RESULTS AND 
      DISCUSSION: Twenty six (21.85%) probands have at least one ill relative. The 
      examined patients who have diseased relatives get ill much earlier than those who 
      do not. Probands with two or more diseased relatives get ill much earlier than 
      those who have just one diseased relative. Analysis of our sample shows a 
      significant statistical difference regarding the onset of illness of diseased 
      parents and their children. Children get ill earlier. CONCLUSIONS: We have 
      concluded that in our sample there is a hereditary component which is related to 
      frequency and onset of psoriasis.
FAU - Belic, Dobrila
AU  - Belic D
AD  - Opsta bolnica "Dorde Joannovic", Dermatovenerolosko odeljenje, Zdravstveni 
      centar, Zrenjanin.
FAU - Ristic-Nikolic, Sonja
AU  - Ristic-Nikolic S
FAU - Damjan, Saveta
AU  - Damjan S
FAU - Ratkov, Iljana
AU  - Ratkov I
FAU - Ceke, Matilda
AU  - Ceke M
LA  - srp
PT  - English Abstract
PT  - Journal Article
TT  - Naslednost psorijaze.
PL  - Serbia
TA  - Med Pregl
JT  - Medicinski pregled
JID - 2985249R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psoriasis/*genetics
EDAT- 2004/10/07 09:00
MHDA- 2004/11/13 09:00
CRDT- 2004/10/07 09:00
PHST- 2004/10/07 09:00 [pubmed]
PHST- 2004/11/13 09:00 [medline]
PHST- 2004/10/07 09:00 [entrez]
AID - 10.2298/mpns0404171b [doi]
PST - ppublish
SO  - Med Pregl. 2004 Mar-Apr;57(3-4):171-4. doi: 10.2298/mpns0404171b.