PMID- 15464217
OWN - NLM
STAT- MEDLINE
DCOM- 20041221
LR  - 20131121
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 153
IP  - 1
DP  - 2004 Oct 15
TI  - Induced fetal depressor or pressor responses associated with c-fos by intravenous 
      or intracerebroventricular losartan.
PG  - 53-60
AB  - Previous fetal studies have indicated depressor responses of intravenous (i.v.) 
      administration of angiotensin antagonists. However, little is known of central 
      effects of angiotensin blockers on fetal cardiovascular controlling. The 
      cardiovascular effects of central administration of the angiotensin-1 (AT(1)) and 
      angiotensin-2 (AT(2)) receptor antagonists, losartan and PD123319, were 
      investigated in the chronically catheterized near-term ovine fetuses. Intravenous 
      losartan produced within 1.5 min a significant and persistent depressor response 
      [maximum Delta mean arterial pressure (MAP)=9 mm Hg] without altering fetal heart 
      rate. Intracerebroventricular (i.c.v.) administration of losartan (1-5 mg/kg) 
      increased fetal arterial pressures (Delta MAP=9-14 mm Hg). Central application of 
      losartan (1 mg/kg) also increased fetal heart rate (maximum Delta heart rate=33 
      beat per minute). Losartan increased c-fos expression in the median preoptic 
      nucleus and paraventricular nuclei in the forebrain, and the tractus solitarius 
      nuclei, the lateral parabrachial nuclei, and the ventrolateral medullabrain. 
      These brain sectors are with abundant AT(1) receptors and have been demonstrated 
      in the involvement in cardiovascular regulation. In contrast, 
      intracerebroventricular injection of the AT(2) receptor antagonist PD123319 had 
      no effect on fetal arterial pressure and heart rate. The results demonstrate 
      strikingly functional differences of losartan on the fetal cardiovascular 
      regulation in central and peripheral sides.
FAU - Shi, Lijun
AU  - Shi L
AD  - Harbor-Ucla Research Institute, Torrance, CA, USA.
FAU - Yao, Jiaming
AU  - Yao J
FAU - Koos, Brian J
AU  - Koos BJ
FAU - Xu, Zhice
AU  - Xu Z
LA  - eng
GR  - HD-18478/HD/NICHD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 11128-99-7 (Angiotensin II)
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - Angiotensin II/metabolism
MH  - Angiotensin II Type 1 Receptor Blockers/*administration & dosage
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Brain/*drug effects/*metabolism
MH  - Cardiovascular System/drug effects
MH  - Cattle
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Fetus
MH  - Genes, fos/*drug effects
MH  - Heart Rate/drug effects
MH  - Immunohistochemistry
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Losartan/*administration & dosage
MH  - Pregnancy
MH  - Renin-Angiotensin System/drug effects/physiology
EDAT- 2004/10/07 09:00
MHDA- 2004/12/22 09:00
CRDT- 2004/10/07 09:00
PHST- 2004/07/19 00:00 [accepted]
PHST- 2004/10/07 09:00 [pubmed]
PHST- 2004/12/22 09:00 [medline]
PHST- 2004/10/07 09:00 [entrez]
AID - S0165-3806(04)00240-8 [pii]
AID - 10.1016/j.devbrainres.2004.07.012 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 2004 Oct 15;153(1):53-60. doi: 
      10.1016/j.devbrainres.2004.07.012.