PMID- 15464328
OWN - NLM
STAT- MEDLINE
DCOM- 20041027
LR  - 20161124
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 44
IP  - 7
DP  - 2004 Oct 6
TI  - Tissue Doppler-derived myocardial acceleration for evaluation of left ventricular 
      diastolic function.
PG  - 1459-66
AB  - OBJECTIVES: Our purpose was to evaluate a tissue Doppler-based index-peak 
      myocardial acceleration (pACC)-during isovolumic relaxation and in evaluating 
      left ventricular (LV) diastolic function. BACKGROUND: Simple, practical indexes 
      for diastolic function evaluation are lacking, but are much desired for clinical 
      evaluation. METHODS: We examined eight sheep by using tissue Doppler ultrasound 
      images obtained in the apical four-chamber views to evaluate mitral valve annular 
      velocity at the septum and LV wall. The pACC thus derived was analyzed during 
      isovolumic relaxation (IVRT) and during the LV filling period (LVFP). We then 
      changed the hemodynamic status of each animal by blood administration, 
      dobutamine, and metoprolol infusion. We compared the pACC values during IVRT and 
      LVFP over the four different hemodynamic conditions with a peak rate of drop in 
      LV pressure (-dP/dt(min)) and the time constant of LV isovolumic pressure decay 
      (tau), as measured with a high-frequency manometer-tipped catheter. RESULTS: The 
      pACC of the septal side of the mitral valve annulus during IVRT showed a good 
      correlation with -dP/dt(min) (r = -0.80, p < 0.0001) and tau (r = -0.87, p < 
      0.0001). The mean left atrial pressure (LAP) correlated well with the septal side 
      pACC during LVFP (r = 0.81, p < 0.0001). There was a weak correlation between the 
      mitral valve annulus pACC at the LV lateral wall and mean LAP. CONCLUSIONS: The 
      pACC during IVRT is a sensitive, preload-independent marker for evaluation of LV 
      diastolic function. In addition, pACC during LVFP correlated well with mean LAP.
FAU - Hashimoto, Ikuo
AU  - Hashimoto I
AD  - Clinical Care Center for Congenital Heart Disease, Oregon Health and Science 
      University, Portland, Oregon 97239-3098, USA.
FAU - Bhat, Aarti Hejmadi
AU  - Bhat AH
FAU - Li, Xiaokui
AU  - Li X
FAU - Jones, Michael
AU  - Jones M
FAU - Davies, Crispin H
AU  - Davies CH
FAU - Swanson, Julia C
AU  - Swanson JC
FAU - Schindera, Sebastian T
AU  - Schindera ST
FAU - Sahn, David J
AU  - Sahn DJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
MH  - Animals
MH  - Cardiac Output
MH  - Coronary Circulation
MH  - Diastole
MH  - *Echocardiography, Doppler
MH  - Feasibility Studies
MH  - Heart Rate
MH  - Heart Ventricles/*diagnostic imaging
MH  - Hemodynamics
MH  - Observer Variation
MH  - Sheep
MH  - *Ventricular Function, Left
EDAT- 2004/10/07 09:00
MHDA- 2004/10/28 09:00
CRDT- 2004/10/07 09:00
PHST- 2003/12/01 00:00 [received]
PHST- 2004/06/23 00:00 [revised]
PHST- 2004/06/29 00:00 [accepted]
PHST- 2004/10/07 09:00 [pubmed]
PHST- 2004/10/28 09:00 [medline]
PHST- 2004/10/07 09:00 [entrez]
AID - S0735-1097(04)01444-5 [pii]
AID - 10.1016/j.jacc.2004.06.067 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2004 Oct 6;44(7):1459-66. doi: 10.1016/j.jacc.2004.06.067.