PMID- 15465089
OWN - NLM
STAT- MEDLINE
DCOM- 20050110
LR  - 20131121
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 225
IP  - 1-2
DP  - 2004 Oct 15
TI  - CCR2-64I polymorphism and CCR5Delta32 deletion in patients with Alzheimer's 
      disease.
PG  - 79-83
AB  - Monocyte chemoattractant protein-1 (MCP-1) and RANTES, as well as their related 
      receptors, have been shown to be involved in Alzheimer's disease (AD) 
      pathogenesis. Genes for their related receptors, CCR2 and CCR5, respectively, are 
      characterized by the presence of two polymorphisms: a conservative change of a 
      valine with an isoleucine at codon 64 of CCR2 (CCR2-64I) and a 32-bp deletion in 
      the coding region of CCR5 (CCR5Delta32), which leads to the expression of a 
      nonfunctional receptor. The distribution of the CCR2-64I and CCR5Delta32 
      polymorphisms was determined in 290 AD patients and in 222 controls. A decreased 
      frequency and an absence of homozygous for the polymorphism CCR2-64I were found, 
      thus suggesting a protective effect of the mutated allele on the occurrence of 
      AD. However, these findings must be cautiously interpreted as the overall 
      significance was found without adjustment for multiple comparisons and is coming 
      from the complete absence of the genotype 64I/64I in AD patients. Conversely, no 
      different distribution of the CCR5Delta32 deletion in the two populations was 
      shown. Stratifying by the presence of ApoE varepsilon4 allele, gender or age at 
      onset, no differences in either allele frequencies were observed.
FAU - Galimberti, Daniela
AU  - Galimberti D
AD  - Department of Neurological Sciences, "Dino Ferrari" Center, University of Milan, 
      IRCCS Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy.
FAU - Fenoglio, Chiara
AU  - Fenoglio C
FAU - Lovati, Carlo
AU  - Lovati C
FAU - Gatti, Alberto
AU  - Gatti A
FAU - Guidi, Ilaria
AU  - Guidi I
FAU - Venturelli, Eliana
AU  - Venturelli E
FAU - Cutter, Gary R
AU  - Cutter GR
FAU - Mariani, Claudio
AU  - Mariani C
FAU - Forloni, Gianluigi
AU  - Forloni G
FAU - Pettenati, Carla
AU  - Pettenati C
FAU - Baron, Pierluigi
AU  - Baron P
FAU - Conti, Giancarlo
AU  - Conti G
FAU - Bresolin, Nereo
AU  - Bresolin N
FAU - Scarpini, Elio
AU  - Scarpini E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Apolipoproteins E)
RN  - 0 (CCR2 protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, CCR5)
RN  - 0 (Receptors, Chemokine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Alzheimer Disease/*genetics
MH  - Apolipoprotein E4
MH  - Apolipoproteins E/genetics
MH  - Chi-Square Distribution
MH  - DNA Mutational Analysis/methods
MH  - Female
MH  - *Gene Deletion
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - RNA, Messenger/biosynthesis
MH  - Receptors, CCR2
MH  - Receptors, CCR5/*genetics
MH  - Receptors, Chemokine/*genetics
MH  - Retrospective Studies
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
MH  - Valine/genetics
EDAT- 2004/10/07 09:00
MHDA- 2005/01/11 09:00
CRDT- 2004/10/07 09:00
PHST- 2004/03/04 00:00 [received]
PHST- 2004/06/28 00:00 [revised]
PHST- 2004/07/02 00:00 [accepted]
PHST- 2004/10/07 09:00 [pubmed]
PHST- 2005/01/11 09:00 [medline]
PHST- 2004/10/07 09:00 [entrez]
AID - S0022-510X(04)00233-3 [pii]
AID - 10.1016/j.jns.2004.07.005 [doi]
PST - ppublish
SO  - J Neurol Sci. 2004 Oct 15;225(1-2):79-83. doi: 10.1016/j.jns.2004.07.005.