PMID- 1546513
OWN - NLM
STAT- MEDLINE
DCOM- 19920416
LR  - 20041117
IS  - 0001-5547 (Print)
IS  - 0001-5547 (Linking)
VI  - 36
IP  - 1
DP  - 1992 Jan-Feb
TI  - Barrett's esophagus. The cytology of dysplasia in comparison to benign and 
      malignant lesions.
PG  - 60-4
AB  - Barrett's esophagus (BE) is the replacement of esophageal squamous epithelium by 
      columnar-lined mucosa and carries an increased risk of carcinoma. Endoscopic 
      surveillance has been suggested, but esophageal brush cytology (BC) has not been 
      widely utilized. Cytologic descriptions of BE, especially dysplasias, are sparse. 
      We studied matched cytologic and histologic materials from 26 patients with BE 
      and 4 patients with concurrent BE and adenocarcinoma. In six patients without 
      dysplasia on biopsy, BE was recognized on BC by the presence of goblet cells 
      within clusters of uniform columnar cells with vesicular nuclei. Dysplasia in 18 
      BC samples revealed small clusters of haphazardly oriented, mildly pleomorphic 
      cells. Their larger nuclei had thickened membranes, evenly dispersed chromatin 
      and occasional multiple nucleoli. The cytologic differentiation of histologically 
      graded low- and high-grade dysplasia was difficult. The carcinoma cases displayed 
      numerous isolated cells exhibiting flagrant malignant features. We conclude that 
      BE lesions are cytologically distinctive and suggest that BC may play a role in 
      surveillance.
FAU - Wang, H H
AU  - Wang HH
AD  - Laboratory Service, Edward J. Hines Veterans Administration Hospital, Hines, 
      Illinois.
FAU - Doria, M I Jr
AU  - Doria MI Jr
FAU - Purohit-Buch, S
AU  - Purohit-Buch S
FAU - Schnell, T
AU  - Schnell T
FAU - Sontag, S
AU  - Sontag S
FAU - Chejfec, G
AU  - Chejfec G
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Acta Cytol
JT  - Acta cytologica
JID - 0370307
SB  - IM
MH  - Adenocarcinoma/*pathology/ultrastructure
MH  - Barrett Esophagus/*pathology
MH  - Cytodiagnosis/methods
MH  - Esophageal Neoplasms/*pathology/ultrastructure
MH  - Humans
MH  - Metaplasia/pathology
EDAT- 1992/01/11 19:15
MHDA- 2001/03/28 10:01
CRDT- 1992/01/11 19:15
PHST- 1992/01/11 19:15 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1992/01/11 19:15 [entrez]
PST - ppublish
SO  - Acta Cytol. 1992 Jan-Feb;36(1):60-4.