PMID- 15465740
OWN - NLM
STAT- MEDLINE
DCOM- 20041108
LR  - 20230216
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 134
IP  - 10
DP  - 2004 Oct
TI  - The effect of dietary fat on LDL size is influenced by apolipoprotein E genotype 
      in healthy subjects.
PG  - 2517-22
AB  - LDL particle size is dependent on both genetic factors and environmental factors 
      such as dietary fat composition. The apolipoprotein E (apoE) genotype is a major 
      genetic determinant of LDL size. Thus, the aim of this work was to study whether 
      the apoE genotype interacts with the quantity and quality of dietary fat, 
      modifying LDL size in young healthy subjects. Healthy subjects (n = 84; 66 apoE 
      3/3, 8 apoE 4/3, 10 apoE 3/2) were subjected to 3 dietary periods, each lasting 4 
      wk. The first was an SFA-enriched diet (38% fat, 20% SFA), which was followed by 
      a carbohydrate (CHO)-rich diet (30% fat, < 10% SFA, 55% carbohydrate) or a 
      monounsaturated fatty acid (MUFA) olive oil-rich diet (38% fat, 22% MUFA) 
      following a randomized crossover design. At the end of each diet period, LDL 
      particle size and plasma levels of total cholesterol, LDL cholesterol (LDL-C), 
      HDL-C, apoB, apoA-I, and triacylglycerols were determined. LDL particle size was 
      significantly higher (P < 0.04) in subjects with the apoE 4/3 genotype compared 
      with those with apoE 3/3 and apoE 3/2 in the basal state. LDL size was smaller (P 
      < 0.02) after the CHO diet than after the MUFA or SFA diets. After the CHO diet, 
      a significant increase in LDL particle size (P < 0.035) was noted with respect to 
      the MUFA diet in apoE 4/3 subjects, whereas a significant decrease was observed 
      in the apoE 3/3 individuals (P < 0.043). In conclusion, a Mediterranean diet, 
      high in MUFA-fat increases LDL particle size compared with a CHO diet, and this 
      effect is dependent of apoE genotypes.
FAU - Moreno, Juan Antonio
AU  - Moreno JA
AD  - Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofia, 
      Cordoba, Spain.
FAU - Perez-Jimenez, Francisco
AU  - Perez-Jimenez F
FAU - Marin, Carmen
AU  - Marin C
FAU - Gomez, Purificacion
AU  - Gomez P
FAU - Perez-Martinez, Pablo
AU  - Perez-Martinez P
FAU - Moreno, Rafael
AU  - Moreno R
FAU - Bellido, Cecilia
AU  - Bellido C
FAU - Fuentes, Francisco
AU  - Fuentes F
FAU - Lopez-Miranda, Jose
AU  - Lopez-Miranda J
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Apolipoproteins E)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids)
RN  - 0 (Fatty Acids, Monounsaturated)
SB  - IM
MH  - Adult
MH  - Apolipoproteins E/*genetics
MH  - Cholesterol, LDL/blood/*drug effects
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/administration & dosage/pharmacology
MH  - Dietary Fats/*pharmacology
MH  - Fatty Acids/administration & dosage/pharmacology
MH  - Fatty Acids, Monounsaturated/administration & dosage/pharmacology
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Particle Size
EDAT- 2004/10/07 09:00
MHDA- 2004/11/09 09:00
CRDT- 2004/10/07 09:00
PHST- 2004/10/07 09:00 [pubmed]
PHST- 2004/11/09 09:00 [medline]
PHST- 2004/10/07 09:00 [entrez]
AID - S0022-3166(23)03080-8 [pii]
AID - 10.1093/jn/134.10.2517 [doi]
PST - ppublish
SO  - J Nutr. 2004 Oct;134(10):2517-22. doi: 10.1093/jn/134.10.2517.