PMID- 15465764
OWN - NLM
STAT- MEDLINE
DCOM- 20041108
LR  - 20230216
IS  - 0022-3166 (Print)
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 134
IP  - 10
DP  - 2004 Oct
TI  - Dietary plasma protein affects the immune response of weaned rats challenged with 
      S. aureus Superantigen B.
PG  - 2667-72
AB  - The aim of this study was to determine the potential modulatory effects of diets 
      supplemented with spray-dried animal plasma (SDAP) or immunoglobulin concentrates 
      (IC) on the immune response of rats challenged with Staphylococcus aureus 
      enterotoxin B (SEB). Lewis rats were fed diets containing 80 g of SDAP/kg diet, 
      22.7 g of IC/kg diet, or milk proteins (Control diet) from postnatal d 21 
      (weaning) for 14 d. On d 30 and 33, rats were given SEB (0.5 mg/kg body weight; 
      i.p.). Organized gut-associated lymphoid tissue (GALT) populations, intestinal 
      secretion, mucosal and serum immunoglobulin concentrations, and neutrophil 
      infiltration were studied. On d 35, blood was collected under anesthesia and 
      samples of intestinal mucosa, Peyer's patches, mesenteric lymph nodes (MLN), and 
      spleen were taken. SEB increased the water content of feces, which was prevented 
      by diets containing either SDAP (P < 0.002) or IC (P < 0.001), indicating that 
      plasma protein-supplemented diets can reverse the SEB-induced secretory response. 
      In Peyer's patches, the diet containing SDAP partially prevented the SEB-induced 
      increase in T lymphocytes (P < 0.1) and reduced the percentage of activated T 
      helper cells (P < 0.05). In MLN, activated T lymphocytes were increased by SEB 
      but they were not affected by diet. No effects of SEB or dietary supplementation 
      on mucosal IgA and serum IgA and IgG were observed. The effects of SDAP 
      supplementation on the lymphocyte populations of GALT in rats challenged with SEB 
      support the view that SDAP can modulate the immune response and suggest that 
      plasma protein supplementation can prevent GALT from possible activation by 
      luminal bacterial superantigens.
FAU - Perez-Bosque, Anna
AU  - Perez-Bosque A
AD  - Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, 
      Barcelona, Spain.
FAU - Pelegri, Carme
AU  - Pelegri C
FAU - Vicario, Maria
AU  - Vicario M
FAU - Castell, Margarida
AU  - Castell M
FAU - Russell, Louis
AU  - Russell L
FAU - Campbell, Joy M
AU  - Campbell JM
FAU - Quigley, James D 3rd
AU  - Quigley JD 3rd
FAU - Polo, Javier
AU  - Polo J
FAU - Amat, Concepcio
AU  - Amat C
FAU - Moreto, Miquel
AU  - Moreto M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Blood Proteins)
RN  - 0 (Enterotoxins)
RN  - 0 (Immunoglobulins)
RN  - 39424-53-8 (enterotoxin B, staphylococcal)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Animals
MH  - Antigens, Bacterial/*immunology
MH  - Blood Proteins/administration & dosage/*immunology
MH  - Diet
MH  - Enterotoxins/*immunology
MH  - Immunoglobulins/administration & dosage/*immunology
MH  - Inflammation/enzymology/immunology
MH  - Intestines/drug effects/immunology
MH  - Lymph Nodes/immunology
MH  - Male
MH  - Peroxidase/metabolism
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Rats, Wistar
MH  - Spleen/immunology
PMC - PMC7107471
EDAT- 2004/10/07 09:00
MHDA- 2004/11/09 09:00
PMCR- 2020/03/31
CRDT- 2004/10/07 09:00
PHST- 2004/10/07 09:00 [pubmed]
PHST- 2004/11/09 09:00 [medline]
PHST- 2004/10/07 09:00 [entrez]
PHST- 2020/03/31 00:00 [pmc-release]
AID - S0022-3166(23)03104-8 [pii]
AID - 10.1093/jn/134.10.2667 [doi]
PST - ppublish
SO  - J Nutr. 2004 Oct;134(10):2667-72. doi: 10.1093/jn/134.10.2667.