PMID- 15466648
OWN - NLM
STAT- MEDLINE
DCOM- 20050624
LR  - 20161124
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Linking)
VI  - 110
IP  - 15
DP  - 2004 Oct 12
TI  - Atherosclerosis in patients infected with HIV is influenced by a mutant monocyte 
      chemoattractant protein-1 allele.
PG  - 2204-9
AB  - BACKGROUND: Patients infected with HIV present with premature atherosclerosis, 
      and the 2 diseases share common pathogenic pathways. We investigated mutations in 
      the monocyte chemoattractant protein-1 (MCP-1) and CCR-2 genes, which are known 
      to control aspects of these pathways, to ascertain whether they are involved in 
      atherogenesis in these patients. METHODS AND RESULTS: We performed carotid and 
      femoral artery ultrasonography to detect subclinical atherosclerosis in patients 
      infected with HIV (n=183). MCP-1-2518G and CCR-2 64I polymorphisms were 
      determined in the HIV group and in a population-based control group (n=348). We 
      also determined MCP-1 circulating levels in the HIV group. The presence of 
      MCP-1-2518G in the group of patients with subclinical atherosclerosis was 
      significantly higher than in patients without atherosclerotic lesions (47.5% 
      versus 18.2%, respectively; P<0.001). Furthermore, the patients with 
      atherosclerotic lesions had higher MCP-1 plasma concentrations than did patients 
      without lesions (74.15 [4.03] versus 57.81 [3.67] pg/mL, respectively; P=0.03). 
      When adjusted for known cardiovascular risk factors, the MCP-1-2518G allele was 
      associated with subclinical atherosclerosis (OR 5.72, 95% CI 1.74 to 18.80, 
      P=0.004). Compared with measurements conducted approximately 2.5 years earlier in 
      a subset of 40 patients, intima-media thickness (IMT) in the carotid artery 
      progressed at a mean rate of 0.06 mm/y more rapidly in patients bearing the 
      MCP-1-mutated allele (P=0.08). CONCLUSIONS: HIV-infected patients with the 
      MCP-1-2518G allele have a 5-fold increased risk for atherosclerosis, as assessed 
      by ultrasonography.
FAU - Alonso-Villaverde, Carlos
AU  - Alonso-Villaverde C
AD  - Servei de Medicina Interna, Hospital Universitari de Sant Joan, 43201 Reus, 
      Spain. cavillaverde@grupsagessa.com
FAU - Coll, Blai
AU  - Coll B
FAU - Parra, Sandra
AU  - Parra S
FAU - Montero, Manuel
AU  - Montero M
FAU - Calvo, Nahum
AU  - Calvo N
FAU - Tous, Monica
AU  - Tous M
FAU - Joven, Jorge
AU  - Joven J
FAU - Masana, Lluis
AU  - Masana L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20041004
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Chemokine)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Alleles
MH  - Arteriosclerosis/blood/*complications/epidemiology/genetics
MH  - C-Reactive Protein/analysis
MH  - Carotid Artery Diseases/blood/complications/diagnostic 
      imaging/epidemiology/genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood/*genetics
MH  - DNA Mutational Analysis
MH  - Female
MH  - Femoral Artery/diagnostic imaging
MH  - Genetic Predisposition to Disease
MH  - HIV Infections/blood/*complications/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic/genetics
MH  - Receptors, CCR2
MH  - Receptors, Chemokine/genetics
MH  - Risk Factors
MH  - Tunica Intima/diagnostic imaging
MH  - Tunica Media/diagnostic imaging
MH  - Ultrasonography
EDAT- 2004/10/07 09:00
MHDA- 2005/06/25 09:00
CRDT- 2004/10/07 09:00
PHST- 2004/10/07 09:00 [pubmed]
PHST- 2005/06/25 09:00 [medline]
PHST- 2004/10/07 09:00 [entrez]
AID - 01.CIR.0000143835.95029.7D [pii]
AID - 10.1161/01.CIR.0000143835.95029.7D [doi]
PST - ppublish
SO  - Circulation. 2004 Oct 12;110(15):2204-9. doi: 10.1161/01.CIR.0000143835.95029.7D. 
      Epub 2004 Oct 4.