PMID- 15467301
OWN - NLM
STAT- MEDLINE
DCOM- 20050404
LR  - 20131121
IS  - 0031-7012 (Print)
IS  - 0031-7012 (Linking)
VI  - 73
IP  - 2
DP  - 2005 Feb
TI  - Nitric oxide and effect of a radical scavenger N-tert-butyl-alpha-phenylnitrone 
      on stroke in a rat model.
PG  - 76-80
AB  - To characterize the role of nitric oxide (NO) in stroke, NO was measured using an 
      in vivo microdialysis technique and electron spin resonance spectrometry in 
      malignant stroke-prone spontaneously hypertensive rats (M-SHRSP), stroke-prone 
      spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY). 
      The brain dialysate NO level was higher in SHRSP than in WKY. NO was not detected 
      in M-SHRSP hippocampus microdialysate after stroke except after the 
      administration of N-tert-butyl-alpha-phenylnitrone (PBN). In addition, very 
      little NO was generated in M-SHRSP brain tissue with hemorrhage. These data 
      demonstrate an association between NO and stroke in M-SHRSP. Further, PBN 
      administration results in maintenance of NO levels after stroke in M-SHRSP.
CI  - Copyright (c) 2005 S. Karger AG, Basel.
FAU - Saito, Kieko
AU  - Saito K
AD  - Institute for Environmental Sciences, University of Shizuoka, Shizuoka, Japan. 
      saitok@smail.u-shizuoka-ken.ac.jp
FAU - Ikeda, Masahiko
AU  - Ikeda M
FAU - Yoshioka, Hisashi
AU  - Yoshioka H
FAU - Tomita, Takako
AU  - Tomita T
LA  - eng
PT  - Journal Article
DEP - 20040930
PL  - Switzerland
TA  - Pharmacology
JT  - Pharmacology
JID - 0152016
RN  - 0 (Cyclic N-Oxides)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Nitrogen Oxides)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 3I91332OPG (phenyl-N-tert-butylnitrone)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - Cyclic N-Oxides
MH  - Free Radical Scavengers/*pharmacology
MH  - Microdialysis
MH  - Nitric Oxide/*biosynthesis
MH  - Nitrogen Oxides/*pharmacology
MH  - Oxidative Stress/physiology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Stroke/*metabolism
EDAT- 2004/10/07 09:00
MHDA- 2005/04/05 09:00
CRDT- 2004/10/07 09:00
PHST- 2003/12/02 00:00 [received]
PHST- 2004/05/19 00:00 [accepted]
PHST- 2004/10/07 09:00 [pubmed]
PHST- 2005/04/05 09:00 [medline]
PHST- 2004/10/07 09:00 [entrez]
AID - 81223 [pii]
AID - 10.1159/000081223 [doi]
PST - ppublish
SO  - Pharmacology. 2005 Feb;73(2):76-80. doi: 10.1159/000081223. Epub 2004 Sep 30.