PMID- 15467369
OWN - NLM
STAT- MEDLINE
DCOM- 20050321
LR  - 20161124
IS  - 1424-859X (Electronic)
IS  - 1424-8581 (Linking)
VI  - 107
IP  - 3-4
DP  - 2004
TI  - Cytological studies of meiotic recombination in human males.
PG  - 249-55
AB  - We combined immunostaining and fluorescence in situ hybridization (FISH) 
      methodology to directly examine meiotic exchanges in over 2,000 pachytene stage 
      spermatocytes from 25 individuals. Our results indicate that, on average, there 
      are about 50 exchanges per cell and that, with the exception of the acrocentric 
      chromosomes, all chromosome arms harbor at least one exchange. We also identified 
      significant among-individual variation in the mean number of exchanges, with an 
      approximate 20% difference between individuals with "low" and those with "high" 
      exchange frequencies.
CI  - Copyright 2004 S. Karger AG, Basel.
FAU - Hassold, T
AU  - Hassold T
AD  - Department of Genetics and The Center for Human Genetics, Case Western Reserve 
      University and University Hospitals of Cleveland, Cleveland VA Medical Center, 
      Cleveland, OH 44106, USA. tjh6@po.cwru.edu
FAU - Judis, L
AU  - Judis L
FAU - Chan, E R
AU  - Chan ER
FAU - Schwartz, S
AU  - Schwartz S
FAU - Seftel, A
AU  - Seftel A
FAU - Lynn, A
AU  - Lynn A
LA  - eng
GR  - P01 HD024605/HD/NICHD NIH HHS/United States
GR  - R01 HD23141/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Cytogenet Genome Res
JT  - Cytogenetic and genome research
JID - 101142708
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (MLH1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
RN  - EC 3.6.1.3 (MutL Protein Homolog 1)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/genetics
MH  - Carrier Proteins
MH  - Chromosomes, Human/genetics/metabolism
MH  - Crossing Over, Genetic/genetics
MH  - Genetic Variation/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Meiosis/*genetics
MH  - Middle Aged
MH  - MutL Protein Homolog 1
MH  - Neoplasm Proteins/metabolism
MH  - Nuclear Proteins
MH  - Recombination, Genetic/*genetics
MH  - Synaptonemal Complex/metabolism
EDAT- 2004/10/07 09:00
MHDA- 2005/03/22 09:00
CRDT- 2004/10/07 09:00
PHST- 2003/11/07 00:00 [received]
PHST- 2004/08/06 00:00 [accepted]
PHST- 2004/10/07 09:00 [pubmed]
PHST- 2005/03/22 09:00 [medline]
PHST- 2004/10/07 09:00 [entrez]
AID - 80602 [pii]
AID - 10.1159/000080602 [doi]
PST - ppublish
SO  - Cytogenet Genome Res. 2004;107(3-4):249-55. doi: 10.1159/000080602.