PMID- 15467627
OWN - NLM
STAT- MEDLINE
DCOM- 20041106
LR  - 20071114
IS  - 0194-5998 (Print)
IS  - 0194-5998 (Linking)
VI  - 131
IP  - 4
DP  - 2004 Oct
TI  - Cyclin D1, p53, MIB1, intratumoral microvessel density, and human papillomavirus 
      in advanced laryngeal carcinoma: association with nodal metastasis.
PG  - 509-13
AB  - OBJECTIVE: We sought to study various parameters in laryngeal squamous cell 
      carcinoma (LSCC) that might predict nodal metastasis. STUDY DESIGN AND SETTING: 
      Sixty-four LSCCs were examined with respect to their histopathology and, using 
      immunohistochemistry, their proliferative capacity (MIB1), p53 and cyclin D1 
      status, and intratumoral microvessel density. The presence of human 
      papillomavirus was ascertained by the polymerase chain reaction. RESULTS: 
      Histopathologically, most tumors had an infiltrating/mixed growth pattern and a 
      diminished inflammatory reaction at the growing margin. In addition, 56% of the 
      tumors were positive for MIB1, with 64% showing p53 overexpression; 70% were 
      positive for cyclin D1; and 59% showed increased tumor microvessel density. Of 42 
      cases analyzed, 9.5% were positive for human papillomavirus 16. CONCLUSIONS: Of 
      the parameters studied, a diminished lymphocytic inflammatory response at the 
      periphery (P < 0.05) and cyclin D1 overexpression (P < 0.001) correlated 
      significantly with cervical nodal metastasis at presentation. SIGNIFICANCE: 
      Cyclin D1 overexpression, easily assessed on biopsy samples, may thus help in 
      optimizing therapy at the outset.
FAU - Kumar, Rekha V
AU  - Kumar RV
AD  - Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India. 
      kvijaykumar@vsnl.com
FAU - Shenoy, Ashok M
AU  - Shenoy AM
FAU - Daniel, Richard
AU  - Daniel R
FAU - Shah, Keerti V
AU  - Shah KV
LA  - eng
GR  - R01-DE13121/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 136601-57-5 (Cyclin D1)
RN  - 148770-78-9 (HIVEP2 protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Carcinoma, Squamous Cell/blood supply/*pathology/virology
MH  - Cyclin D1/*analysis
MH  - DNA-Binding Proteins/*analysis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/blood supply/chemistry/*pathology/virology
MH  - Lymphatic Metastasis/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Papillomaviridae/*isolation & purification
MH  - Polymerase Chain Reaction
MH  - Transcription Factors
MH  - Tumor Suppressor Protein p53/*analysis
EDAT- 2004/10/07 09:00
MHDA- 2004/11/09 09:00
CRDT- 2004/10/07 09:00
PHST- 2004/10/07 09:00 [pubmed]
PHST- 2004/11/09 09:00 [medline]
PHST- 2004/10/07 09:00 [entrez]
AID - S0194599804003250 [pii]
AID - 10.1016/j.otohns.2004.03.029 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2004 Oct;131(4):509-13. doi: 
      10.1016/j.otohns.2004.03.029.