PMID- 15468193
OWN - NLM
STAT- MEDLINE
DCOM- 20051123
LR  - 20061115
IS  - 1099-498X (Print)
IS  - 1099-498X (Linking)
VI  - 6
IP  - 11
DP  - 2004 Nov
TI  - Exploiting dendritic cells for cancer immunotherapy: genetic modification of 
      dendritic cells.
PG  - 1175-88
AB  - Dendritic cells (DCs) are pivotal regulators of immune reactivity and immune 
      tolerance. The observation that DCs can recruit naive T cells has invigorated 
      cancer immunology and led to the proposal of DCs as the basis for vaccines 
      designed for the treatment of cancer. Designing effective strategies to load DCs 
      with antigens is a challenging field of research. The successful realization of 
      gene transfer to DCs will be highly dependent on the employed vector system. 
      Here, we review various viral and non-viral gene transfer systems, and discuss 
      their distinct characteristics and possible advantages and disadvantages in 
      respect to their use in DC-based immunotherapy.
FAU - Breckpot, Karine
AU  - Breckpot K
AD  - Laboratory of Molecular and Cellular Therapy, Department of Physiology and 
      Immunology, Medical School of the Vrije Universiteit Brussel, 1090 Brussels, 
      Belgium.
FAU - Heirman, Carlo
AU  - Heirman C
FAU - Neyns, Bart
AU  - Neyns B
FAU - Thielemans, Kris
AU  - Thielemans K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Gene Med
JT  - The journal of gene medicine
JID - 9815764
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Cancer Vaccines/*immunology
MH  - Dendritic Cells/cytology/*immunology/metabolism
MH  - *Gene Transfer Techniques
MH  - Genetic Vectors
MH  - Humans
MH  - Immunotherapy
MH  - Neoplasms/immunology/*therapy
MH  - Viruses/genetics
RF  - 180
EDAT- 2004/10/07 09:00
MHDA- 2005/12/13 09:00
CRDT- 2004/10/07 09:00
PHST- 2004/10/07 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2004/10/07 09:00 [entrez]
AID - 10.1002/jgm.615 [doi]
PST - ppublish
SO  - J Gene Med. 2004 Nov;6(11):1175-88. doi: 10.1002/jgm.615.