PMID- 15468376
OWN - NLM
STAT- MEDLINE
DCOM- 20050721
LR  - 20081121
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 31
IP  - 10
DP  - 2004 Oct
TI  - Polymorphisms in the promoter region of RANTES and the regulatory region of 
      monocyte chemoattractant protein-1 among Chinese children with systemic lupus 
      erythematosus.
PG  - 2062-7
AB  - OBJECTIVE: Chemokines play an important role in the physiology and 
      pathophysiology of acute and chronic inflammatory processes. We investigated 
      whether chemokines such as RANTES (regulated upon activation, normally T cell 
      expressed and secreted) promoter and monocyte chemoattractant protein-1 (MCP-1) 
      regulatory polymorphisms were associated with systemic lupus erythematosus (SLE) 
      in Chinese children. METHODS: Forty-six patients with SLE and 107 healthy 
      children of comparable ages were studied for genotypes with polymerase chain 
      reaction-based assays. RESULTS: The frequency and distribution of genotypes of 
      the -28(C/G) RANTES gene polymorphism were significantly different between the 2 
      groups (p < 0.001), and the RANTES -28G allele was significantly more frequent in 
      patients with SLE than in healthy controls (23.9% vs 11%; p = 0.006, OR 2.37, 95% 
      CI 1.25-4.28). There was no significant difference in the frequency or in the 
      distribution of genotypes of the -2518(A/G) MCP-1 and the -403(G/A) RANTES gene 
      polymorphisms between patients and controls (p = 0.32 and p = 0.19, 
      respectively). The RANTES -28G allele was also significantly associated with 
      higher initial levels of antinuclear antibody, lower levels of C3, and higher 
      incidences of central nervous system lupus. CONCLUSION: In the Chinese 
      population, children with RANTES -28C/G polymorphisms have increased risk of 
      developing SLE. Healthy controls with the C/G or G/G genotype were 2.37 times 
      more likely to have SLE compared to those with the C/C genotype.
FAU - Liao, Chiang-Hua
AU  - Liao CH
AD  - Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University, 
      Taoyuan, Taiwan.
FAU - Yao, Tsung-Chieh
AU  - Yao TC
FAU - Chung, Hung-Tao
AU  - Chung HT
FAU - See, Lai-Chu
AU  - See LC
FAU - Kuo, Ming-Ling
AU  - Kuo ML
FAU - Huang, Jing-Long
AU  - Huang JL
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
SB  - IM
MH  - Adolescent
MH  - Chemokine CCL2/*genetics
MH  - Chemokine CCL5/*genetics
MH  - Child
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*genetics/immunology
MH  - Male
MH  - *Polymorphism, Genetic
MH  - *Promoter Regions, Genetic
MH  - *Regulatory Sequences, Nucleic Acid
EDAT- 2004/10/07 09:00
MHDA- 2005/07/22 09:00
CRDT- 2004/10/07 09:00
PHST- 2004/10/07 09:00 [pubmed]
PHST- 2005/07/22 09:00 [medline]
PHST- 2004/10/07 09:00 [entrez]
AID - 0315162X-31-2062 [pii]
PST - ppublish
SO  - J Rheumatol. 2004 Oct;31(10):2062-7.