PMID- 15469082
OWN - NLM
STAT- MEDLINE
DCOM- 20050830
LR  - 20181130
IS  - 0412-3948 (Print)
IS  - 0412-3948 (Linking)
VI  - 39
IP  - 6
DP  - 2004 Jun
TI  - [Expression of survivin gene and its relationship with expression of p15, p16 
      proteins in laryngeal squamous cell carcinomas].
PG  - 356-9
AB  - OBJECTIVE: : To investigate the expression of Survivin (SVV) and its relationship 
      with expression of p15, p16 in laryngeal squamous cell carcinoma (LSCC). METHODS: 
      Using strep avidin-biotin complex (SABC) method, we examined the expression of 
      SVV, p15 and p16 gene in 48 LSCC tissus samples, 24 normal laryngeal mucosa 
      tissus samples and 24 normal laryngeal tissus adjacent to the tumors samples. 
      RESULTS: SVV was expression in 27 of 48 (56.3%) samples of LSCC and expression in 
      6 of 24 (25.0%) samples of normal laryngeal tissus adjacent to the tumors. Normal 
      laryngeal mocosa tissus samples did not expressed SVV. Overexpression of SVV was 
      related to the tumor site, grade, clinical stage and tumor prognosis (P < 0.05). 
      The expression of SVV in LSCC was positive correlated with p16 expression( C = 
      0.52 P < 0.001), but not with p15 expression. CONCLUSION: SVV may play a role in 
      the pathway of carcinogenesis and tumor progress. It is feasible for early 
      diagnosis and prognosis estimation. Overexpression of SVV gene and de-activation 
      of antioncogene p16 may be play synergetic roles in the carcinogenesis of LSCC.
FAU - Zhu, Jin
AU  - Zhu J
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Hangzhou First People's 
      Hospital, Clinical Institute of Medical Science in Zhejiang Province, Hangzhou 
      310006, China. zhujinhyh@yahoo.com.cn
FAU - Xu, Ru-Jun
AU  - Xu RJ
FAU - Wu, Zheng-Hu
AU  - Wu ZH
FAU - Yan, Chun-Lan
AU  - Yan CL
FAU - Cao, Xiao-Lin
AU  - Cao XL
FAU - Fang, Yu
AU  - Fang Y
FAU - Lin, Lin
AU  - Lin L
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Ke Za Zhi
JT  - Zhonghua er bi yan hou ke za zhi
JID - 16210350R
RN  - 0 (BIRC5 protein, human)
RN  - 0 (CDKN2B protein, human)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p15)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Survivin)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/genetics/*metabolism
MH  - Cell Cycle Proteins/*biosynthesis
MH  - Cyclin-Dependent Kinase Inhibitor p15
MH  - Cyclin-Dependent Kinase Inhibitor p16/*biosynthesis
MH  - Female
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins
MH  - Laryngeal Neoplasms/genetics/*metabolism
MH  - Male
MH  - Microtubule-Associated Proteins/*biosynthesis
MH  - Middle Aged
MH  - Neoplasm Proteins
MH  - Survivin
MH  - Tumor Suppressor Proteins/*biosynthesis
EDAT- 2004/10/08 09:00
MHDA- 2005/09/01 09:00
CRDT- 2004/10/08 09:00
PHST- 2004/10/08 09:00 [pubmed]
PHST- 2005/09/01 09:00 [medline]
PHST- 2004/10/08 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Ke Za Zhi. 2004 Jun;39(6):356-9.