PMID- 15469970
OWN - NLM
STAT- MEDLINE
DCOM- 20041223
LR  - 20191210
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 131
IP  - 21
DP  - 2004 Nov
TI  - FGF and PI3 kinase signaling pathways antagonistically modulate sex muscle 
      differentiation in C. elegans.
PG  - 5381-92
AB  - Myogenesis in vertebrate myocytes is promoted by activation of the 
      phosphatidyl-inositol 3'-kinase (PI3 kinase) pathway and inhibited by fibroblast 
      growth factor (FGF) signaling. We show that hyperactivation of the Caenorhabditis 
      elegans FGF receptor, EGL-15, similarly inhibits the differentiation of the 
      hermaphrodite sex muscles. Activation of the PI3 kinase signaling pathway can 
      partially suppress this differentiation defect, mimicking the antagonistic 
      relationship between these two pathways known to influence vertebrate myogenesis. 
      When ectopically expressed in body wall muscle precursor cells, hyperactivated 
      EGL-15 can also interfere with the proper development of the body wall 
      musculature. Hyperactivation of EGL-15 has also revealed additional effects on a 
      number of fundamental processes within the postembryonic muscle lineage, such as 
      cell division polarity. These studies provide important in vivo insights into the 
      contribution of FGF signaling events to myogenesis.
FAU - Sasson, Isaac E
AU  - Sasson IE
AD  - Yale University School of Medicine, Department of Genetics, I-354 SHM, PO Box 
      208005, New Haven, CT 06520-8005, USA.
FAU - Stern, Michael J
AU  - Stern MJ
LA  - eng
GR  - GM07205/GM/NIGMS NIH HHS/United States
GR  - GM50504/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20041006
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (EGL-15 protein, C elegans)
RN  - 0 (Phosphoinositide-3 Kinase Inhibitors)
RN  - 0 (Protein Isoforms)
RN  - 0 (Receptors, Fibroblast Growth Factor)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Animals
MH  - Caenorhabditis elegans/cytology/*growth & development/*metabolism
MH  - Caenorhabditis elegans Proteins/antagonists & inhibitors/genetics/*metabolism
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Fibroblast Growth Factors/antagonists & inhibitors/metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Muscle Development
MH  - Muscles/cytology/enzymology/*metabolism
MH  - Myoblasts/cytology/metabolism
MH  - Phenotype
MH  - Phosphatidylinositol 3-Kinases/*metabolism
MH  - Phosphoinositide-3 Kinase Inhibitors
MH  - Protein Isoforms/genetics/metabolism
MH  - Receptors, Fibroblast Growth Factor/antagonists & inhibitors/genetics/*metabolism
MH  - *Sex Differentiation
MH  - *Signal Transduction
EDAT- 2004/10/08 09:00
MHDA- 2004/12/24 09:00
CRDT- 2004/10/08 09:00
PHST- 2004/10/08 09:00 [pubmed]
PHST- 2004/12/24 09:00 [medline]
PHST- 2004/10/08 09:00 [entrez]
AID - dev.01423 [pii]
AID - 10.1242/dev.01423 [doi]
PST - ppublish
SO  - Development. 2004 Nov;131(21):5381-92. doi: 10.1242/dev.01423. Epub 2004 Oct 6.