PMID- 15470535
OWN - NLM
STAT- MEDLINE
DCOM- 20041216
LR  - 20051116
IS  - 1221-4167 (Print)
IS  - 1221-4167 (Linking)
VI  - 13
IP  - 3
DP  - 2004 Sep
TI  - Barrett's Esophagus.
PG  - 219-22
AB  - Barrett's esophagus is an alteration of the esophageal epithelium, regardless of 
      length, evidenced by endoscopic examination (protrusion of the gastric mucosa 
      into the esophagus in the shape of a flame) and confirmed by histological 
      examination of the bioptic samples (intestinal metaplasia with mucosecretory 
      cells). It develops following long-term gastro-esophageal reflux (GER). The 
      documented risk factors are: long-term GER (duration more than 5 years), age over 
      50 years, male sex, Caucasian race, aggressiveness of the refluxed material, 
      individual susceptibility of the esophageal mucosa to the refluxed material. The 
      carcinogenic risk is 30 times higher than in the general population. Treatment 
      targets the acid reflux, with proton pump inhibitors (PPI), prevention of 
      carcinogenesis with cyclooxygenase 2 inhibitors, ablation of the metaplastic area 
      by laser, plasma-argon mucosectomy, or photodynamic therapy and antireflux 
      surgery.
FAU - Pascu, Oliviu
AU  - Pascu O
AD  - 3rd Medical Clinic, University of Medicine and Pharmacy, Str. Croitorilor 19-21, 
      400162 Cluj-Napoca, Romania.
FAU - Lencu, Monica
AU  - Lencu M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Romania
TA  - Rom J Gastroenterol
JT  - Romanian journal of gastroenterology
JID - 9315667
SB  - IM
MH  - Barrett Esophagus/*diagnosis/etiology/*therapy
MH  - Gastroesophageal Reflux/complications
MH  - Humans
RF  - 23
EDAT- 2004/10/08 09:00
MHDA- 2004/12/17 09:00
CRDT- 2004/10/08 09:00
PHST- 2004/10/08 09:00 [pubmed]
PHST- 2004/12/17 09:00 [medline]
PHST- 2004/10/08 09:00 [entrez]
AID - 7 [pii]
PST - ppublish
SO  - Rom J Gastroenterol. 2004 Sep;13(3):219-22.