PMID- 15470645
OWN - NLM
STAT- MEDLINE
DCOM- 20050623
LR  - 20191109
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 10
IP  - 5
DP  - 2004 Oct
TI  - Age, functional capacity, and health-related quality of life in patients with 
      heart failure.
PG  - 368-73
AB  - BACKGROUND: Although heart failure disproportionately affects older persons and 
      is associated with significant physical disability, existing data on physical 
      limitations and health-related quality of life (HRQL) derive largely from studies 
      of younger subjects. We compared the relationship between functional limitation 
      and HRQL between older and younger patients with heart failure. METHODS AND 
      RESULTS: We evaluated 546 outpatients with heart failure enrolled in a 
      multicenter prospective cohort study. At baseline and 6 +/- 2 weeks later, 
      functional status was assessed by New York Heart Association (NYHA) 
      classification and 6-minute walk testing. HRQL was measured with the Kansas City 
      Cardiomyopathy Questionnaire (KCCQ). Comparing older (age >65 years, n = 218) and 
      younger patients (n = 328), we assessed baseline HRQL across strata of functional 
      status. In the 484 patients who completed follow-up (194 older and 290 younger 
      patients), we also assessed the changes in HRQL associated with changes in 
      functional status over time. At baseline, older patients had better HRQL than 
      younger patients (mean KCCQ score 60 +/- 25 versus 54 +/- 28, P = .005) in spite 
      of worse NYHA class (mean 2.54 versus 2.35, P < .001) and lower 6-minute walk 
      distances (824 +/- 378 versus 1064 +/- 371 feet, P < .001). After multivariable 
      adjustment including baseline NYHA class, older age was independently correlated 
      with better HRQL (beta = +7.9 points, P < .001). At follow-up, older patients 
      with a deterioration in NYHA class experienced marked declines in HRQL compared 
      with younger patients (mean HRQL change of -14.4 points versus +0.3 points, 
      respectively, P < .001). Analyses using 6-minute walk distance as the functional 
      measure yielded similar results. CONCLUSIONS: Although older patients with heart 
      failure have relatively good HRQL in spite of significant functional limitations, 
      they are at risk for worsening HRQL with further decline in functional status. 
      These results underscore the importance of treatments aimed at maintaining 
      functional status in older persons with heart failure, including those with 
      significant baseline functional limitations.
FAU - Masoudi, Frederick A
AU  - Masoudi FA
AD  - Department of Medicine, Denver Health Medical Center, Colorado 80204, USA.
FAU - Rumsfeld, John S
AU  - Rumsfeld JS
FAU - Havranek, Edward P
AU  - Havranek EP
FAU - House, John A
AU  - House JA
FAU - Peterson, Eric D
AU  - Peterson ED
FAU - Krumholz, Harlan M
AU  - Krumholz HM
FAU - Spertus, John A
AU  - Spertus JA
CN  - Cardiovascular Outcomes Research Consortium
LA  - eng
GR  - K08-AG01011/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Health Status
MH  - Heart Failure/*physiopathology/*psychology
MH  - Humans
MH  - Linear Models
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prospective Studies
MH  - Quality of Life/*psychology
MH  - Surveys and Questionnaires
EDAT- 2004/10/08 09:00
MHDA- 2005/06/24 09:00
CRDT- 2004/10/08 09:00
PHST- 2004/10/08 09:00 [pubmed]
PHST- 2005/06/24 09:00 [medline]
PHST- 2004/10/08 09:00 [entrez]
AID - S1071916404000193 [pii]
AID - 10.1016/j.cardfail.2004.01.009 [doi]
PST - ppublish
SO  - J Card Fail. 2004 Oct;10(5):368-73. doi: 10.1016/j.cardfail.2004.01.009.