PMID- 15470650
OWN - NLM
STAT- MEDLINE
DCOM- 20050623
LR  - 20191109
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 10
IP  - 5
DP  - 2004 Oct
TI  - Variability in the clinical status of patients with advanced heart failure.
PG  - 397-402
AB  - BACKGROUND: The importance of repeated clinical assessments of patients with 
      heart failure is widely accepted. The frequency of such follow-up is not 
      established and is likely to depend on the natural history and variability of 
      patients' health status and the availability and use of appropriate treatments. 
      METHODS AND RESULTS: We analyzed data from a multicenter prospective cohort study 
      of heart failure outpatients comparing baseline variables including New York 
      Heart Association (NYHA) class, summary score on the Kansas City Cardiomyopathy 
      Questionnaire (KCCQ), and performance on a 6-minute walk test with results of a 
      repeat evaluation at 6 weeks. We also compared patient and physician assessment 
      of change in disease status among patients with advanced symptoms (NYHA class III 
      with a recent antecedent hospitalization or class IV) and those with milder 
      degrees of limitation (NYHA classes I, II, and stable III). Patients with 
      advanced symptoms had greater short-term variability in health status as 
      reflected by the KCCQ summary score and a visual analog scale. A greater 
      proportion of patients with advanced heart failure experienced moderate or 
      greater clinical change. Patient and physician global assessments were congruent 
      with more direct measures of health status. CONCLUSION: Patients with advanced 
      heart failure have greater short-term variability in status, supporting the need 
      for frequent clinical follow-up and appropriate power calculations for clinical 
      trials that are designed to measure meaningful changes over a short period.
FAU - Hauptman, Paul J
AU  - Hauptman PJ
AD  - Department of Medicine, Saint Louis University School of Medicine, Missouri, USA.
FAU - Masoudi, Frederick A
AU  - Masoudi FA
FAU - Weintraub, William S
AU  - Weintraub WS
FAU - Pina, Ileana
AU  - Pina I
FAU - Jones, Philip G
AU  - Jones PG
FAU - Spertus, John A
AU  - Spertus JA
CN  - Cardiovascular Outcomes Research Consortium
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Arrhythmias, Cardiac/physiopathology
MH  - Cohort Studies
MH  - Exercise Test
MH  - *Exercise Tolerance
MH  - Female
MH  - Follow-Up Studies
MH  - *Health Status
MH  - Heart Failure/*physiopathology/*psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Surveys and Questionnaires
EDAT- 2004/10/08 09:00
MHDA- 2005/06/24 09:00
CRDT- 2004/10/08 09:00
PHST- 2004/10/08 09:00 [pubmed]
PHST- 2005/06/24 09:00 [medline]
PHST- 2004/10/08 09:00 [entrez]
AID - S1071916403008108 [pii]
AID - 10.1016/j.cardfail.2003.12.008 [doi]
PST - ppublish
SO  - J Card Fail. 2004 Oct;10(5):397-402. doi: 10.1016/j.cardfail.2003.12.008.