PMID- 15470653
OWN - NLM
STAT- MEDLINE
DCOM- 20050623
LR  - 20191109
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 10
IP  - 5
DP  - 2004 Oct
TI  - Prediction of mortality in chronic heart failure from peak oxygen consumption 
      adjusted for either body weight or lean tissue.
PG  - 421-6
AB  - BACKGROUND: Peak oxygen consumption (pVO2) reflects oxygen extraction from the 
      skeletal muscles, but is routinely corrected for body weight. We hypothesized 
      that correcting pVO2 for lean tissue rather than total body weight would improve 
      the prediction of prognosis in patients with chronic heart failure (CHF). METHODS 
      AND RESULTS: A total of 272 CHF outpatients (mean age 61 +/- 12 years, New York 
      Heart Association [NYHA] class 2.3 +/- 0.8) underwent a cardiopulmonary exercise 
      testing and body composition assessment by dual-energy X-ray absorptiometry. 
      During a median follow-up of 608 days (range 8-3656), 75 patients died. 
      Univariate survival analysis showed strong survival prediction from pVO2 adjusted 
      for total weight or lean tissue (chi2 17.7, P < .001; chi2 27.5, P < .0001, 
      respectively). Both predicted survival significantly in bivariate analysis, (chi2 
      4.6, P = .032; chi2 16.6, P < .0001). The predictive effects were independent of 
      exercise protocol (treadmill versus cycle ergometer) (both P < .001). 
      Multivariate analysis showed that pVO2 adjusted for lean tissue had prognostic 
      importance independently of NYHA class, ejection fraction, and ventilation and 
      carbon dioxide production slope (P < .05 for each). In patients with NYHA class I 
      and II (n = 160), pVO2 adjusted for lean tissue predicted outcome (P = .03). 
      CONCLUSION: Adjustment for lean tissue instead for body weight increases the 
      prognostic power of pVO2, particularly in patients with mild heart failure.
FAU - Cicoira, Mariantonietta
AU  - Cicoira M
AD  - Divisione Clinicizzata di Cardiologia, Universita degli Studi di Verona, Italy.
FAU - Davos, Constantinos H
AU  - Davos CH
FAU - Francis, Darrel P
AU  - Francis DP
FAU - Doehner, Wolfram
AU  - Doehner W
FAU - Zanolla, Luisa
AU  - Zanolla L
FAU - Franceschini, Lorenzo
AU  - Franceschini L
FAU - Piepoli, Massimo F
AU  - Piepoli MF
FAU - Coats, Andrew J S
AU  - Coats AJ
FAU - Zardini, Piero
AU  - Zardini P
FAU - Poole-Wilson, Philip A
AU  - Poole-Wilson PA
FAU - Anker, Stefan D
AU  - Anker SD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Absorptiometry, Photon
MH  - Area Under Curve
MH  - Body Composition
MH  - *Body Weight
MH  - Chronic Disease
MH  - Exercise Test
MH  - Exercise Tolerance
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*metabolism/*mortality/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxygen Consumption
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - ROC Curve
MH  - Survival Analysis
EDAT- 2004/10/08 09:00
MHDA- 2005/06/24 09:00
CRDT- 2004/10/08 09:00
PHST- 2004/10/08 09:00 [pubmed]
PHST- 2005/06/24 09:00 [medline]
PHST- 2004/10/08 09:00 [entrez]
AID - S107191640300811X [pii]
AID - 10.1016/j.cardfail.2003.12.009 [doi]
PST - ppublish
SO  - J Card Fail. 2004 Oct;10(5):421-6. doi: 10.1016/j.cardfail.2003.12.009.