PMID- 15471934
OWN - NLM
STAT- MEDLINE
DCOM- 20050531
LR  - 20061115
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 19
IP  - 12
DP  - 2004 Dec
TI  - Comparison of blastocyst transfer with or without preimplantation genetic 
      diagnosis for aneuploidy screening in couples with advanced maternal age: a 
      prospective randomized controlled trial.
PG  - 2849-58
AB  - BACKGROUND: It is generally accepted that the age-related increased aneuploidy 
      rate is correlated with reduced implantation and a higher abortion rate. 
      Therefore, advanced maternal age (AMA) couples are a good target group to assess 
      the possible benefit of preimplantation genetic diagnosis for aneuploidy 
      screening (PGD-AS) on the outcome after assisted reproductive technology (ART). 
      METHODS: A prospective randomized controlled clinical trial (RCT) was carried out 
      comparing the outcome after blastocyst transfer combined with PGD-AS using 
      fluorescence in situ hybridization (FISH) for the chromosomes X, Y, 13, 16, 18, 
      21 and 22 in AMA couples (aged > or =37 years) with a control group without 
      PGD-AS. From the 400 (200 for PGD-AS and 200 controls) couples that were 
      allocated to the trial, an oocyte pick-up was performed effectively in 289 cycles 
      (148 PGD-AS cycles and 141 control cycles). RESULTS: Positive serum HCG rates per 
      transfer and per cycle were the same for PGD-AS and controls: 35.8% (19.6%) 
      [%/per embryo transfer (per cycle)] and 32.2% (27.7%), respectively (NS). 
      Significantly fewer embryos were transferred in the PGD-AS group than in the 
      control group (P<0.001). The implantation rate (with fetal heart beat) was 17.1% 
      in the PGD-AS group versus 11.5% in the control group (not significant; P=0.09). 
      We observed a normal diploid status in 36.8% of the embryos. CONCLUSIONS: This 
      RCT provides no arguments in favour of PGD-AS for improving clinical outcome per 
      initiated cycle in patients with AMA when there are no restrictions in the number 
      of embryos to be transferred.
FAU - Staessen, Catherine
AU  - Staessen C
AD  - Centre for Reproductive Medicine, University Hospital, Dutch-speaking Brussels 
      Free University (Vrije Universiteit Brussel), Laarbeeklaan 101, B-1090 Brussels, 
      Belgium. catherine.staessen@az.vub.ac.be
FAU - Platteau, Peter
AU  - Platteau P
FAU - Van Assche, Elvire
AU  - Van Assche E
FAU - Michiels, An
AU  - Michiels A
FAU - Tournaye, Herman
AU  - Tournaye H
FAU - Camus, Michel
AU  - Camus M
FAU - Devroey, Paul
AU  - Devroey P
FAU - Liebaers, Inge
AU  - Liebaers I
FAU - Van Steirteghem, Andre
AU  - Van Steirteghem A
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20041007
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
CIN - Hum Reprod. 2005 Aug;20(8):2362-3; author reply 2364-5. PMID: 16024540
CIN - Hum Reprod. 2005 Aug;20(8):2363-4; author reply 2364-5. PMID: 16024542
MH  - Adult
MH  - *Aneuploidy
MH  - Blastocyst/*physiology
MH  - Embryo Transfer/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - *Maternal Age
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - *Preimplantation Diagnosis
MH  - Prospective Studies
EDAT- 2004/10/09 09:00
MHDA- 2005/06/01 09:00
CRDT- 2004/10/09 09:00
PHST- 2004/10/09 09:00 [pubmed]
PHST- 2005/06/01 09:00 [medline]
PHST- 2004/10/09 09:00 [entrez]
AID - deh536 [pii]
AID - 10.1093/humrep/deh536 [doi]
PST - ppublish
SO  - Hum Reprod. 2004 Dec;19(12):2849-58. doi: 10.1093/humrep/deh536. Epub 2004 Oct 7.