PMID- 15473133
OWN - NLM
STAT- MEDLINE
DCOM- 20050628
LR  - 20191026
IS  - 0743-5800 (Print)
IS  - 0743-5800 (Linking)
VI  - 30
IP  - 2
DP  - 2004 May
TI  - Familial acromegaly: a familial report and review of the literature.
PG  - 239-45
AB  - Familial acromegaly without features of multiple endocrine neoplasie type 1 (MEN 
      1) is an exceptional clinical entity. We report in this article three cases of 
      acromegaly due to pituitary macroadenomas without any other endocrinopathy in a 
      family. A 31-year-old woman (subject A) and her 34-year-old sister (subject B) 
      with elevated basal rolactin (PRL) levels, elevated growth hormone (GH) levels 
      during the oral glucose tolerance test (OGTT) and a pituitary adenoma in Computed 
      Tomography (CT) and Magnetic Resonance Imaging (MRI) were diagnosed as 
      acromegaly. Subject A was treated only with radiotherapy and Lysuride. Subject B 
      underwent transsphenoidal microsurgical extirpation 15 years ago. 11 years later 
      her 24-year-old son (subject C) also presented with typical signs of acromegaly, 
      elevated basal PRL level and elevated GH levels during OGTT. A pituitary 
      macroadenoma was identified by MRI and he also underwent transsphenoidal 
      adenomectomy. Pathology reports confirmed the diagnosis of GH-secreting pituitary 
      adenoma in subject B and C. Immunocytochemistry revealed that tumours of subject 
      B (> 20% of tumour cells) and C (> 50% of tumour cells) were positive for GH. 
      Tumours of subject B (> 10% of tumour cells) and C (> 50% of tumour cells) also 
      exhibited immunoreactivity for PRL. On investigation of histocompatibility 
      antigens, it was observed that the subject A, B, and C shared the same haplotypes 
      [HLA A24(9), HLA B13(6), HLA B35, HLA DQ7(3), HLA DR13(6)] and so it is very 
      possible that investigation of HLA antigens in patients with pituitary tumour, 
      contributes to better identification of its familial nature and frequency. Here 
      we describe an acromegaly family and the distributions of HLA antigens.
FAU - Tiryakioglu, Ozay
AU  - Tiryakioglu O
AD  - Division of Endocrinology-Metabolism and Diabetes, Cerrahpasa Medical Faculty, 
      University of Istanbul, Istanbul, Turkey. droztr@yahoo.com
FAU - Caneroglu, Nurhan U
AU  - Caneroglu NU
FAU - Yilmaz, Erkan
AU  - Yilmaz E
FAU - Gazioglu, Nurperi
AU  - Gazioglu N
FAU - Kadioglu, Pinar
AU  - Kadioglu P
FAU - Acbay, Ozer
AU  - Acbay O
FAU - Gundogdu, Sadi
AU  - Gundogdu S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - England
TA  - Endocr Res
JT  - Endocrine research
JID - 8408548
RN  - 0 (HLA Antigens)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - 9002-62-4 (Prolactin)
SB  - IM
MH  - Acromegaly/etiology/*genetics/immunology
MH  - Adenoma/complications/genetics/metabolism
MH  - Adult
MH  - Female
MH  - HLA Antigens/blood
MH  - Human Growth Hormone/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Pituitary Neoplasms/complications/genetics/metabolism
MH  - Prolactin/metabolism
RF  - 27
EDAT- 2004/10/12 09:00
MHDA- 2005/06/29 09:00
CRDT- 2004/10/12 09:00
PHST- 2004/10/12 09:00 [pubmed]
PHST- 2005/06/29 09:00 [medline]
PHST- 2004/10/12 09:00 [entrez]
AID - 10.1081/erc-120039568 [doi]
PST - ppublish
SO  - Endocr Res. 2004 May;30(2):239-45. doi: 10.1081/erc-120039568.