PMID- 15473298
OWN - NLM
STAT- MEDLINE
DCOM- 20041028
LR  - 20181130
IS  - 0379-4172 (Print)
IS  - 0379-4172 (Linking)
VI  - 31
IP  - 2
DP  - 2004 Feb
TI  - [Association of homozygous deletion of p15 and p16 gene and amplification of EGFR 
      gene in laryngeal squamous cell carcinoma].
PG  - 109-13
AB  - To assess the relationship of deletion of p15 and p16 gene and EGFR gene 
      amplification in laryngeal squamous cell carcinoma (LSCC). DNA was extracted from 
      fresh tumor. Deletion of p15 exon 2(p15E2) and p16 exon 2(p16E2) in 30 cases of 
      LSCC was detected by polymerase chain reaction (PCR) technique. Amplification of 
      EGFR gene in 30 cases of LSCC was detected by FISH. The rate of p15E2 deletion in 
      30 cases was 13.3(4/30), and that of p16E2 was 16.7% (5/30). p15E2 and p16E2 
      codeletion rate was 6.7% (2/30). The rate of EGFR gene amplification in 30 cases 
      was 30% (9/30), and was amplified 2 to 8 fold. Homozygous deletion of p16E2 and 
      p15E2 and codeletion is related with amplification of EGFR gene (P = 0.000018), 
      and may play an important role to oncogenesis and malignant progression in LSCC.
FAU - Li, Fu-Cai
AU  - Li FC
AD  - Department of Medical Genetics, China Medical University, Shenyang 110001, China. 
      Fucaili@hotmail.com
FAU - Li, Ying-Hui
AU  - Li YH
FAU - Zhao, Xui
AU  - Zhao X
FAU - Fu, Wei-Neng
AU  - Fu WN
FAU - Xu, Zhen-Ming
AU  - Xu ZM
FAU - Li, Zeng-Gang
AU  - Li ZG
FAU - Sun, Kai-Lai
AU  - Sun KL
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Yi Chuan Xue Bao
JT  - Yi chuan xue bao = Acta genetica Sinica
JID - 7900784
RN  - 0 (CDKN2B protein, human)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p15)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Cell Cycle Proteins/*genetics
MH  - Cyclin-Dependent Kinase Inhibitor p15
MH  - ErbB Receptors/*genetics
MH  - *Gene Deletion
MH  - *Genes, p16
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Laryngeal Neoplasms/*genetics
MH  - Tumor Suppressor Proteins/*genetics
EDAT- 2004/10/12 09:00
MHDA- 2004/10/29 09:00
CRDT- 2004/10/12 09:00
PHST- 2004/10/12 09:00 [pubmed]
PHST- 2004/10/29 09:00 [medline]
PHST- 2004/10/12 09:00 [entrez]
PST - ppublish
SO  - Yi Chuan Xue Bao. 2004 Feb;31(2):109-13.