PMID- 15474609
OWN - NLM
STAT- MEDLINE
DCOM- 20050114
LR  - 20131121
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 25
IP  - 6
DP  - 2004 Dec
TI  - The neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA) and 
      methamphetamine on serotonin, dopamine, and GABA-ergic terminals: an in-vitro 
      autoradiographic study in rats.
PG  - 905-14
AB  - Damage to serotonin (5-HT) terminals following doses of 
      3,4-methylenedioxymethamphetamine (MDMA) is well documented, and this toxicity is 
      thought to be related to dopamine release that is potentiated by the 5-HT(2A/2C) 
      agonist effects of the drug. Although MDMA and methamphetamine (METH) have some 
      similar dopaminergic activities, they differ in their 5-HT agonistic properties. 
      It is reasoned that the study of the resultant toxicity following equimolar doses 
      of MDMA and METH on both dopamine and 5-HT terminals should offer a comparison of 
      the ability of these drugs to induce neurotoxicity. In order to measure the toxic 
      effects to the brain, rats were given equimolar doses of MDMA (40 mg/kg/day) and 
      METH (32 mg/kg/day) in subcutaneously implanted osmotic minipumps for a period of 
      5 days, and in-vitro autoradiography using [3H]-paroxetine, [3H]-mazindol, 
      [3H]-methylspiperone, and [3H]-flunitrazepam, was performed on brain sections. 
      The results showed that METH was more toxic to 5-HT terminals than MDMA in 
      forebrain regions, including the anterior cingulate, caudate nucleus, nucleus 
      accumbens, and septum. METH was also more toxic than MDMA to dopamine terminals 
      in the habenula, and posterior retrosplenial cortex. Therefore, we find that METH 
      was more toxic to 5-HT and dopamine terminals in specific brain regions in both 
      pre and post-synaptic sites following continuous equimolar dosing.
FAU - Armstrong, Brian D
AU  - Armstrong BD
AD  - Department of Psychiatry and Biobehavioral Science, University of California at 
      Los Angeles, NPI 760 Westwood Plaza Room 67-373, Los Angeles, CA 90024, USA. 
      barmstrong@mednet.ucla.edu
FAU - Noguchi, Kevin K
AU  - Noguchi KK
LA  - eng
GR  - DA 07344/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Receptors, Dopamine)
RN  - 0 (Receptors, GABA)
RN  - 0 (Receptors, Serotonin)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Female
MH  - Methamphetamine/metabolism/*toxicity
MH  - N-Methyl-3,4-methylenedioxyamphetamine/metabolism/*toxicity
MH  - Presynaptic Terminals/drug effects/metabolism
MH  - Protein Binding/drug effects/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine/*metabolism
MH  - Receptors, GABA/*metabolism
MH  - Receptors, Serotonin/*metabolism
EDAT- 2004/10/12 09:00
MHDA- 2005/01/15 09:00
CRDT- 2004/10/12 09:00
PHST- 2004/04/14 00:00 [received]
PHST- 2004/06/10 00:00 [accepted]
PHST- 2004/10/12 09:00 [pubmed]
PHST- 2005/01/15 09:00 [medline]
PHST- 2004/10/12 09:00 [entrez]
AID - S0161-813X(04)00083-X [pii]
AID - 10.1016/j.neuro.2004.06.003 [doi]
PST - ppublish
SO  - Neurotoxicology. 2004 Dec;25(6):905-14. doi: 10.1016/j.neuro.2004.06.003.