PMID- 15475079
OWN - NLM
STAT- MEDLINE
DCOM- 20041202
LR  - 20101118
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 28
IP  - 12
DP  - 2004 Dec
TI  - Complex cytogenetics in a case of probably work related MDS/AML.
PG  - 1357-61
AB  - In the majority of cases of overt acute myeloid leukemia (AML), there is no 
      knowledge about a preleukemic phase of myelodysplastic syndrome (MDS). A few 
      recent case-control studies suggest an association between MDS and several 
      occupations. We report a unique case of MDS/AML related to the patient's work 
      condition with numerous cytostatic agents. The karyotype revealed a spectrum of 
      genetic rearrangements identified by conventional cytogenetics, fluorescence in 
      situ hybridization (FISH) and spectral karyotyping (SKY). We suggest that 
      amplification of chromosomal material may play a greater role in leukemogenesis 
      than has been recognized previously.
FAU - Salamanchuk, Zoriana
AU  - Salamanchuk Z
AD  - Department of Hematology, Jagiellonian University Medical College, Kopernika 17, 
      31-501 Krakow, Poland. salaman@hemat.cm-uj.krakow.pl
FAU - Jakobczyk, Malgorzata
AU  - Jakobczyk M
FAU - Nowak, Wieslaw
AU  - Nowak W
FAU - Skotnicki, Aleksander B
AU  - Skotnicki AB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (Alkylating Agents)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Topoisomerase II Inhibitors)
SB  - IM
MH  - Acute Disease
MH  - Alkylating Agents/adverse effects
MH  - Antineoplastic Agents/*adverse effects
MH  - Bone Marrow Examination
MH  - *Cytogenetic Analysis
MH  - Enzyme Inhibitors/adverse effects
MH  - Female
MH  - Gene Duplication
MH  - Gene Rearrangement
MH  - Humans
MH  - Leukemia, Myeloid/etiology/*genetics
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/chemically induced/etiology/*genetics
MH  - Occupational Exposure/*adverse effects
MH  - Topoisomerase II Inhibitors
EDAT- 2004/10/12 09:00
MHDA- 2004/12/16 09:00
CRDT- 2004/10/12 09:00
PHST- 2003/11/20 00:00 [received]
PHST- 2004/04/07 00:00 [accepted]
PHST- 2004/10/12 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/10/12 09:00 [entrez]
AID - S0145212604001286 [pii]
AID - 10.1016/j.leukres.2004.04.005 [doi]
PST - ppublish
SO  - Leuk Res. 2004 Dec;28(12):1357-61. doi: 10.1016/j.leukres.2004.04.005.