PMID- 15475178
OWN - NLM
STAT- MEDLINE
DCOM- 20041116
LR  - 20181130
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 154
IP  - 1-2
DP  - 2004 Dec 1
TI  - Ethosuximide and valproate display high efficacy against lindane-induced seizures 
      in mice.
PG  - 55-60
AB  - Both lindane (gamma-hexachlorocyclohexane), an organochlorine ectoparasiticide 
      and pentylenetetrazol, used as a model of experimental epilepsy, produce 
      convulsive seizures resulting from the blockade of the gamma-aminobutyric acid 
      (GABAA) receptor. In the present study we established the protective effects of 
      ethosuximide and valproate against seizures induced by lindane and compared them 
      with the well-known protective effects of these drugs against 
      pentylenetetrazol-induced seizures in mice. Both ethosuximide and valproate 
      afforded complete and dose-dependent protection against seizures induced by 
      lindane. However, the potencies of these drugs were lower than those obtained 
      against pentylenetetrazol seizures. Nevertheless, the protective efficacy of 
      ethosuximide and valproate against experimentally induced lindane seizures may 
      suggest possible efficacy of these drugs against seizures in lindane-poisoned 
      patients.
FAU - Kaminski, Rafal M
AU  - Kaminski RM
AD  - Isotope Laboratory, Institute of Agricultural Medicine, Jaczewskiego 8, 20-950 
      Lublin, Poland. kaminskr@ninds.nih.gov
FAU - Tochman, Anna M
AU  - Tochman AM
FAU - Dekundy, Andrzej
AU  - Dekundy A
FAU - Turski, Waldemar A
AU  - Turski WA
FAU - Czuczwar, Stanislaw J
AU  - Czuczwar SJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Anticonvulsants)
RN  - 0 (GABA Agents)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - 5SEH9X1D1D (Ethosuximide)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - WM5Z385K7T (Pentylenetetrazole)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/administration & dosage/*therapeutic use
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Drug Therapy, Combination
MH  - Ethosuximide/administration & dosage/*therapeutic use
MH  - GABA Agents/administration & dosage/*therapeutic use
MH  - *Hexachlorocyclohexane/administration & dosage/toxicity
MH  - Injections, Intraperitoneal
MH  - Injections, Subcutaneous
MH  - Male
MH  - Mice
MH  - Pentylenetetrazole/toxicity
MH  - Seizures/chemically induced/physiopathology/*prevention & control
MH  - Valproic Acid/administration & dosage/*therapeutic use
EDAT- 2004/10/12 09:00
MHDA- 2004/11/17 09:00
CRDT- 2004/10/12 09:00
PHST- 2004/01/08 00:00 [received]
PHST- 2004/07/02 00:00 [revised]
PHST- 2004/07/02 00:00 [accepted]
PHST- 2004/10/12 09:00 [pubmed]
PHST- 2004/11/17 09:00 [medline]
PHST- 2004/10/12 09:00 [entrez]
AID - S0378-4274(04)00337-6 [pii]
AID - 10.1016/j.toxlet.2004.07.002 [doi]
PST - ppublish
SO  - Toxicol Lett. 2004 Dec 1;154(1-2):55-60. doi: 10.1016/j.toxlet.2004.07.002.