PMID- 15476610
OWN - NLM
STAT- MEDLINE
DCOM- 20041202
LR  - 20061115
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 94
IP  - 8
DP  - 2004 Oct 15
TI  - Prognostic usefulness of plasma monocyte/macrophage and T-lymphocyte activation 
      markers in patients with acute coronary syndromes.
PG  - 993-6
AB  - Macrophages and T lymphocytes accumulate and are activated in atherosclerotic 
      plaques. We tested the hypothesis that plasma levels of the monocyte/macrophage 
      and T-lymphocyte activation markers, monocyte chemoattractant protein-1 (MCP-1) 
      and soluble interleukin-2 receptor (sIL-2r), respectively, can be used in acute 
      coronary syndrome classification and risk prediction. Blood samples were 
      collected at hospital admissions of 183 patients who had ischemic chest pain. Of 
      these, 59 had acute myocardial infarction, 60 had unstable angina, and 64 had 
      angina pectoris. No significant differences in the levels or proportions of 
      subjects with increased levels of MCP-1 or sIL-2r were found across groups. 
      During a mean follow-up of 13 months, 117 patients (64%) had a study end point 
      (i.e., cardiac death, recurrent myocardial infarction, unstable angina, or 
      revascularization). Increased levels (above median) of MCP-1 and sIL-2r were 
      associated with increased risk, with odds ratios of 1.85 (95% confidence interval 
      0.92 to 3.73, p = 0.08) and 2.34 (95% confidence interval 1.16 to 4.71, p <0.02), 
      respectively. In summary, in this unselected patient population with a very high 
      rate of coronary events during follow-up, increased plasma levels of MCP-1 and 
      sIL-2r were helpful for predicting new coronary events.
FAU - Kervinen, Helena
AU  - Kervinen H
AD  - Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
FAU - Manttari, Matti
AU  - Manttari M
FAU - Kaartinen, Maija
AU  - Kaartinen M
FAU - Makynen, Heikki
AU  - Makynen H
FAU - Palosuo, Timo
AU  - Palosuo T
FAU - Pulkki, Kari
AU  - Pulkki K
FAU - Kovanen, Petri T
AU  - Kovanen PT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Macrophage-Activating Factors)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angina, Unstable/*blood/immunology
MH  - Chemokine CCL2/blood
MH  - Female
MH  - Humans
MH  - Lymphocyte Activation
MH  - Macrophage-Activating Factors/*blood
MH  - Macrophages/*immunology
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*immunology
MH  - Myocardial Infarction/*blood/immunology
MH  - Prognosis
MH  - Syndrome
MH  - T-Lymphocytes/*immunology
EDAT- 2004/10/13 09:00
MHDA- 2004/12/16 09:00
CRDT- 2004/10/13 09:00
PHST- 2004/02/27 00:00 [received]
PHST- 2004/06/25 00:00 [revised]
PHST- 2004/06/25 00:00 [accepted]
PHST- 2004/10/13 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/10/13 09:00 [entrez]
AID - S0002-9149(04)01059-8 [pii]
AID - 10.1016/j.amjcard.2004.06.052 [doi]
PST - ppublish
SO  - Am J Cardiol. 2004 Oct 15;94(8):993-6. doi: 10.1016/j.amjcard.2004.06.052.