PMID- 15477509
OWN - NLM
STAT- MEDLINE
DCOM- 20041203
LR  - 20061115
IS  - 0003-9942 (Print)
IS  - 0003-9942 (Linking)
VI  - 61
IP  - 10
DP  - 2004 Oct
TI  - Recurrent lymphocytic meningitis: the role of herpesviruses.
PG  - 1553-7
AB  - BACKGROUND: Herpes simplex virus 2 (HSV-2) and HSV-1 have been recognized as 
      causes of recurrent aseptic lymphocytic meningitis (RALM). However, the role of 
      other herpesviruses has not been systematically assessed. OBJECTIVES: To evaluate 
      the cause of RALM by using polymerase chain reaction (PCR) tests detecting 
      varicella-zoster virus (VZV), cytomegalovirus (CMV), or human herpesvirus 6 
      (HHV-6), in addition to HSV, on cerebrospinal fluid (CSF) samples; and to assess 
      the utility of PCR and antibody analyses in consecutive episodes of RALM. DESIGN: 
      The PCR and antibody results for herpesviruses were analyzed from 14 patients 
      having 48 episodes of RALM. RESULTS: The CSF PCR results for VZV, CMV, and HHV-6 
      were negative in 12, 10, and 11 patients investigated, respectively, and 
      antibodies against VZV, CMV, and HHV-6 showed only old immunity. Herpes simplex 
      virus 2 was detected from the CSF in 10 patients, and HSV-1 in 1 patient. In 6 of 
      these 11 patients, the HSV PCR result was positive in more than one disease 
      episode. A significant increase of serum antibodies for HSV was seen in only 1 of 
      15 episodes examined. An intrathecal antibody response to HSV was not recognized 
      in 9 episodes investigated in these 11 patients. CONCLUSIONS: We could not find 
      evidence of VZV, CMV, or HHV-6 in the pathogenesis of RALM, although most 
      patients were previously infected by those viruses. Herpes simplex virus 2 was 
      detected from the CSF in most patients, and often repeatedly, which further 
      confirms the role of this virus in RALM. The causative diagnosis was obtained 
      only by PCR, whereas antibody analysis was not clinically useful.
FAU - Kupila, Laura
AU  - Kupila L
AD  - Departments of Neurology, Turku University Central Hospital, 20520 Turku, 
      Finland. laura.kupila@tyks.fi
FAU - Vainionpaa, Raija
AU  - Vainionpaa R
FAU - Vuorinen, Tytti
AU  - Vuorinen T
FAU - Marttila, Reijo J
AU  - Marttila RJ
FAU - Kotilainen, Pirkko
AU  - Kotilainen P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Neurol
JT  - Archives of neurology
JID - 0372436
SB  - IM
MH  - Adult
MH  - Cerebrospinal Fluid/virology
MH  - Cytomegalovirus/genetics/pathogenicity
MH  - Cytomegalovirus Infections/cerebrospinal fluid/etiology/virology
MH  - Female
MH  - Herpesviridae Infections/cerebrospinal fluid/*complications/virology
MH  - Herpesvirus 3, Human/genetics/isolation & purification/pathogenicity
MH  - Herpesvirus 6, Human/genetics/isolation & purification/*pathogenicity
MH  - Humans
MH  - Lymphocytic Choriomeningitis/cerebrospinal fluid/etiology/*virology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction/methods
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
EDAT- 2004/10/13 09:00
MHDA- 2004/12/16 09:00
CRDT- 2004/10/13 09:00
PHST- 2004/10/13 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/10/13 09:00 [entrez]
AID - 61/10/1553 [pii]
AID - 10.1001/archneur.61.10.1553 [doi]
PST - ppublish
SO  - Arch Neurol. 2004 Oct;61(10):1553-7. doi: 10.1001/archneur.61.10.1553.