PMID- 15477664
OWN - NLM
STAT- MEDLINE
DCOM- 20050303
LR  - 20191109
IS  - 0257-277X (Print)
IS  - 0257-277X (Linking)
VI  - 30
IP  - 2
DP  - 2004
TI  - Rethinking the role of Src family protein tyrosine kinases in the allergic 
      response: new insights on the functional coupling of the high affinity IgE 
      receptor.
PG  - 241-53
AB  - Antigen-induced cross-linking of immunoglobulin E (IgE) antibodies bound to the 
      high-affinity IgE receptor (FcepsilonRI), on mast cells results in the release of 
      mediators that initiate an inflammatory response. This normal immune response has 
      been abducted by immunological adaptation, through the production of IgE 
      antibodies to normally innocuous substances, to cause allergic disease. 
      Therefore, understanding the molecular requirements in IgE-dependent mast-cell 
      activation holds promise for therapeutic intervention in disease. Recent 
      investigation on the functional coupling of FcepsilonRI to the intracellular 
      signaling apparatus has provided paradigm-altering insights on the importance and 
      function of Src family protein tyrosine kinases (Src PTK) in mast-cell 
      activation. In this synopsis, we review the current knowledge on the role of the 
      Src PTKs, Fyn and Lyn, in mast-cell activation and discuss the implications of 
      our findings on allergic disease.
FAU - Furumoto, Yasuko
AU  - Furumoto Y
AD  - Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, 
      National Institute of Arthritis and Musculoskeletal and Skin Diseases, National 
      Institutes of Health, Bethesda, MD 20892, USA.
FAU - Gonzalez-Espinosa, Claudia
AU  - Gonzalez-Espinosa C
FAU - Gomez, Gregorio
AU  - Gomez G
FAU - Kovarova, Martina
AU  - Kovarova M
FAU - Odom, Sandra
AU  - Odom S
FAU - Parravicini, Valentino
AU  - Parravicini V
FAU - Ryana, John J
AU  - Ryana JJ
FAU - Rivera, Juan
AU  - Rivera J
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Immunol Res
JT  - Immunologic research
JID - 8611087
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 2.7.10.2 (src-Family Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Hypersensitivity/*immunology/pathology
MH  - Immunoglobulin E/immunology
MH  - Mast Cells/*immunology/pathology
MH  - Mice
MH  - Receptors, IgE/immunology
MH  - Signal Transduction/*immunology
MH  - src-Family Kinases/*immunology
RF  - 67
EDAT- 2004/10/13 09:00
MHDA- 2005/03/04 09:00
CRDT- 2004/10/13 09:00
PHST- 2004/10/13 09:00 [pubmed]
PHST- 2005/03/04 09:00 [medline]
PHST- 2004/10/13 09:00 [entrez]
AID - IR:30:2:241 [pii]
AID - 10.1385/ir:30:2:241 [doi]
PST - ppublish
SO  - Immunol Res. 2004;30(2):241-53. doi: 10.1385/ir:30:2:241.