PMID- 15478146
OWN - NLM
STAT- MEDLINE
DCOM- 20050111
LR  - 20151119
IS  - 0004-3591 (Print)
IS  - 0004-3591 (Linking)
VI  - 51
IP  - 5
DP  - 2004 Oct 15
TI  - Serum levels of matrix metalloproteinase 3 and macrophage colony-stimulating 
      factor 1 correlate with disease activity in ankylosing spondylitis.
PG  - 691-9
AB  - OBJECTIVE: To assess the usefulness of measuring serum matrix metalloproteinase 3 
      (MMP-3) and macrophage colony-stimulating factor (M-CSF) in patients with 
      ankylosing spondylitis (AS). METHODS: Serum levels of MMP-3 and M-CSF were 
      measured in AS patients who did and did not receive infliximab treatment. These 
      were compared with those of 28 healthy subjects. RESULTS: In the group of AS 
      patients not treated with biologics, both M-CSF and MMP-3 correlated with the 
      Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) values, but not with 
      each other. Logistic regression analysis showed that MMP-3 values were high in 
      those with severely active disease. Infusions of infliximab in AS patients led to 
      a significant decrease in the values of the BASDAI as well as the serum MMP-3, 
      but no change in the serum M-CSF values. CONCLUSION: MMP-3 and M-CSF are 
      potentially useful markers of AS disease activity.
FAU - Yang, Chunhua
AU  - Yang C
AD  - University of California Los Angeles, USA.
FAU - Gu, Jieruo
AU  - Gu J
FAU - Rihl, Markus
AU  - Rihl M
FAU - Baeten, Dominique
AU  - Baeten D
FAU - Huang, Feng
AU  - Huang F
FAU - Zhao, Miansong
AU  - Zhao M
FAU - Zhang, Hanwei
AU  - Zhang H
FAU - Maksymowych, Walter P
AU  - Maksymowych WP
FAU - De Keyser, Filip
AU  - De Keyser F
FAU - Veys, Eric M
AU  - Veys EM
FAU - Yu, David T Y
AU  - Yu DT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Biomarkers)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
RN  - B72HH48FLU (Infliximab)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Antibodies, Monoclonal/therapeutic use
MH  - Biomarkers
MH  - Female
MH  - Humans
MH  - Infliximab
MH  - Macrophage Colony-Stimulating Factor/*blood/genetics
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood/genetics
MH  - Middle Aged
MH  - Oligonucleotide Array Sequence Analysis
MH  - Severity of Illness Index
MH  - Spondylitis, Ankylosing/*blood/drug therapy/genetics
EDAT- 2004/10/13 09:00
MHDA- 2005/01/12 09:00
CRDT- 2004/10/13 09:00
PHST- 2004/10/13 09:00 [pubmed]
PHST- 2005/01/12 09:00 [medline]
PHST- 2004/10/13 09:00 [entrez]
AID - 10.1002/art.20696 [doi]
PST - ppublish
SO  - Arthritis Rheum. 2004 Oct 15;51(5):691-9. doi: 10.1002/art.20696.