PMID- 15479874
OWN - NLM
STAT- MEDLINE
DCOM- 20041207
LR  - 20181113
IS  - 0003-4967 (Print)
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 63 Suppl 2
IP  - Suppl 2
DP  - 2004 Nov
TI  - Mitogen activated protein kinases as targets for development of novel 
      anti-inflammatory drugs.
PG  - ii62-ii64
AB  - Given the prevalence and debilitating nature of chronic inflammatory diseases 
      there is a never ending quest for identification of novel targets for the 
      rational development of anti-inflammatory drugs. Although the major signalling 
      pathway that controls inflammation associated gene expression is the one leading 
      to activation of transcription factor NF-kappaB, considerable attention has also 
      been given to mitogen activated protein kinases (MAPKs) as likely targets for 
      development of novel anti-inflammatory therapeutics. Indeed, inhibitors targeting 
      these pathways have been developed and preliminary preclinical data suggest that 
      they exhibit anti-inflammatory activity. This report focuses on the possible 
      mechanisms through which such inhibitors may interfere with inflammation and 
      discusses the pros and cons of targeting MAPKs in the treatment of chronic 
      inflammatory disease.
FAU - Karin, M
AU  - Karin M
AD  - Laboratory of Gene Regulation and Signal Transduction, Department of 
      Pharmacology, School of Medicine, University of California, San Diego, 9500 
      Gilman Drive, La Jolla, CA 92093-0723, USA. karinoffice@ucsd.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Anti-Inflammatory Agents)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Humans
MH  - Inflammation/drug therapy/enzymology
MH  - Mitogen-Activated Protein Kinases/*antagonists & inhibitors/physiology
PMC - PMC1766783
EDAT- 2004/10/14 09:00
MHDA- 2004/12/16 09:00
PMCR- 2007/11/01
CRDT- 2004/10/14 09:00
PHST- 2004/10/14 09:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/10/14 09:00 [entrez]
PHST- 2007/11/01 00:00 [pmc-release]
AID - 63/suppl_2/ii62 [pii]
AID - 10.1136/ard.2004.028274 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2004 Nov;63 Suppl 2(Suppl 2):ii62-ii64. doi: 
      10.1136/ard.2004.028274.