PMID- 15480178
OWN - NLM
STAT- MEDLINE
DCOM- 20041103
LR  - 20190713
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 78
IP  - 7
DP  - 2004 Oct 15
TI  - Impact of HLA-A,B,C allele mismatches on outcome after unrelated blood stem cell 
      transplantation in whites.
PG  - 1077-80
AB  - At our institution the selection of unrelated donors for hematopoietic stem cell 
      transplantation (HSCT) relies on low resolution human leukocyte antigen (HLA)-A,B 
      and high resolution HLA-DRB1,DQB1 DNA-based typing. To answer the question of 
      whether routine high resolution HLA-A,B,C typing might improve HSCT outcome, 171 
      white "HLA-identical" donor/recipient pairs, as stated by our pretransplant 
      tissue typing routine, were retyped for HLA-A,B,C using sequence based typing 
      (SBT). The numbers of HLA-A,B,C allele mismatches detected by SBT were correlated 
      to established clinical endpoints of HSCT outcome. We found 33.9% of the study 
      transplants to be fully HLA-A,B,C matched, whereas 66.1 % exhibited one through 
      four donor/recipient HLA-A,B,C allele mismatches. However, statistical analysis 
      could not demonstrate an impact of the number of HLA-A,B,C allele mismatches on 
      overall survival and other analyzed endpoints. Thus, our series of white 
      donor/recipient pairs does not suggest the routine use of HLA-A,B,C SBT to 
      improve HSCT outcome substantially.
FAU - Ottinger, H D
AU  - Ottinger HD
AD  - Department of Bone Marrow Transplantation, University Hospital of Essen, Germany.
FAU - Ferencik, S
AU  - Ferencik S
FAU - Beelen, D W
AU  - Beelen DW
FAU - Lindemann, M
AU  - Lindemann M
FAU - Peceny, R
AU  - Peceny R
FAU - Elmaagacli, A H
AU  - Elmaagacli AH
FAU - Grosse-Wilde, H
AU  - Grosse-Wilde H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - *Alleles
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - *Hematopoietic Stem Cell Transplantation
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Multivariate Analysis
MH  - Retrospective Studies
EDAT- 2004/10/14 09:00
MHDA- 2004/11/04 09:00
CRDT- 2004/10/14 09:00
PHST- 2004/10/14 09:00 [pubmed]
PHST- 2004/11/04 09:00 [medline]
PHST- 2004/10/14 09:00 [entrez]
AID - 00007890-200410150-00021 [pii]
AID - 10.1097/01.tp.0000137791.28140.93 [doi]
PST - ppublish
SO  - Transplantation. 2004 Oct 15;78(7):1077-80. doi: 
      10.1097/01.tp.0000137791.28140.93.