PMID- 15482516
OWN - NLM
STAT- MEDLINE
DCOM- 20050201
LR  - 20220330
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 15
IP  - 5
DP  - 2004 Oct
TI  - Effect of BCG vaccination in asthmatic schoolchildren.
PG  - 415-20
AB  - Recent studies have explored the effect of Bacilli Calmette-Guerin (BCG) or 
      Mycobacterium vaccae vaccination in asthmatic patients, yielding conflicting 
      results. We investigated the effect of BCG vaccination in asthmatic 
      schoolchildren, especially focusing on the cytokine pattern released by 
      mononuclear cells. After a 1-yr run-in period, 67 asthmatic schoolchildren 
      received intradermal immunization with BCG (33 patients) or placebo (34 
      patients). Both groups were followed during 1 yr. Serum immunoglobulin E (IgE) 
      levels did not change after BCG (407.1 +/- 86.6 vs. 415.1 +/- 86.7 IU/ml, mean 
      +/- s.e.m.), but increased after placebo (406.7 +/- 67.0 vs. 619.7 +/- 90.7 
      IU/ml, p = 0.001) administration. Interleukin (IL)-4 and interferon (IFN)-gamma 
      measured in the supernatant of stimulated cultured blood mononuclear cells did 
      not change in the BCG group (10.8 +/- 2.3 vs. 17.9 +/- 5.7 pg/ml, and 348.6 +/- 
      118.0 vs. 354.8 +/- 139.0 pg/ml, respectively), while in the control group IL-4 
      increased (from 6.7 +/- 1.3 to 16.1 +/- 6.0 pg/ml, p < 0.05), and IFN-gamma 
      decreased (from 279.9 +/- 82.1 to 232.1 +/- 109.6 pg/ml, p = 0.01). In comparison 
      with their initial status, most patients maintained the same asthma severity and 
      the same proportion of emergency room visits at the end of the study. The 
      proportion of those in whom asthma improved or worsened was the same in both 
      groups. We concluded that, contrary to the common hypothesis, BCG vaccination in 
      asthmatic children was unable to cause a long-term reinforcement of Th(1) 
      response, although it could avoid the increased Th(2) response observed in 
      control patients.
FAU - Vargas, Mario H
AU  - Vargas MH
AD  - Departamento de Investigacion en Asma, Instituto Nacional de Enfermedades 
      Respiratorias, Tlalpan 4502, CP 14080, Mexico DF. mhvargash@yahoo.com.mx
FAU - Bernal-Alcantara, Demetrio A
AU  - Bernal-Alcantara DA
FAU - Vaca, Miguel A
AU  - Vaca MA
FAU - Franco-Marina, Francisco
AU  - Franco-Marina F
FAU - Lascurain, Ricardo
AU  - Lascurain R
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (BCG Vaccine)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Asthma/*immunology
MH  - BCG Vaccine/*adverse effects
MH  - Child
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interferon-gamma/immunology/metabolism
MH  - Interleukin-4/immunology/metabolism
MH  - Male
MH  - Th1 Cells/immunology
MH  - Th2 Cells/immunology
EDAT- 2004/10/16 09:00
MHDA- 2005/02/03 09:00
CRDT- 2004/10/16 09:00
PHST- 2004/10/16 09:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/10/16 09:00 [entrez]
AID - PAI198 [pii]
AID - 10.1111/j.1399-3038.2004.00198.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2004 Oct;15(5):415-20. doi: 
      10.1111/j.1399-3038.2004.00198.x.