PMID- 15482517
OWN - NLM
STAT- MEDLINE
DCOM- 20050201
LR  - 20080528
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 15
IP  - 5
DP  - 2004 Oct
TI  - Food allergy and atopic dermatitis in infancy: an epidemiologic study.
PG  - 421-7
AB  - Atopic dermatitis is common in infancy. The role of food allergy in atopic 
      dermatitis of infancy is unclear. We examined the relationship between atopic 
      dermatitis and immunoglobulin E (IgE)-mediated food allergy in infancy. A birth 
      cohort of 620 infants with a family history of eczema, asthma, hayfever or 
      immediate food allergy in a parent or sibling: 487 children had complete data 
      including skin prick tests (SPTs) to evaluate IgE-mediated food allergy to cow 
      milk, egg and peanut. Participants were grouped as no atopic dermatitis (Gp 0) or 
      in quartiles of increasing severity of atopic dermatitis (Gps 1-4) quantified by 
      days of topical steroid use as reported monthly. Adverse reactions to foods were 
      recorded. The cumulative prevalence of atopic dermatitis was 28.9% to 12 months 
      (10.3% of the cohort of moderate severity). As atopic dermatitis severity 
      increased so did the prevalence of IgE-mediated food allergy (Gp 0, 40/346 vs. Gp 
      1, 6/36 vs. Gp 2, 8/35 vs. Gp 3, 12/35 vs. Gp 4, 24/35; chi(2) = 76; p < 10(-6)), 
      and the frequency of reported adverse food allergy reactions (Gp 0, 43/346 vs. Gp 
      1, 4/36 vs. Gp 2, 8/35, vs. Gp 3, 5/35, vs. Gp 4, 13/35; chi(2) = 17; p = 0.002). 
      The relative risk of an infant with atopic dermatitis having IgE-mediated food 
      allergy is 5.9 for the most severely affected group. Atopic dermatitis is common 
      in infancy. There is a strong association between IgE-mediated food allergy and 
      atopic dermatitis in this age group.
FAU - Hill, D J
AU  - Hill DJ
AD  - Department of Allergy, Royal Children's Hospital, Flemington Road, Parkville, 
      Victoria 3052, Australia. allergy.clinic@rch.org.au
FAU - Hosking, C S
AU  - Hosking CS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
SB  - IM
MH  - Dermatitis, Atopic/*complications/*epidemiology
MH  - Female
MH  - Food Hypersensitivity/*complications/*epidemiology
MH  - Humans
MH  - Hypersensitivity, Immediate/complications/epidemiology
MH  - Infant
MH  - Male
MH  - Skin Tests
EDAT- 2004/10/16 09:00
MHDA- 2005/02/03 09:00
CRDT- 2004/10/16 09:00
PHST- 2004/10/16 09:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/10/16 09:00 [entrez]
AID - PAI178 [pii]
AID - 10.1111/j.1399-3038.2004.00178.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2004 Oct;15(5):421-7. doi: 
      10.1111/j.1399-3038.2004.00178.x.