PMID- 15482519
OWN - NLM
STAT- MEDLINE
DCOM- 20050201
LR  - 20220309
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 15
IP  - 5
DP  - 2004 Oct
TI  - The diagnostic value of skin prick testing in children with food allergy.
PG  - 435-41
AB  - The diagnostic accuracy of the skin prick test (SPT) in food allergy is 
      controversial. We have developed diagnostic cut-off levels for SPT in children 
      with allergy to cow milk, egg and peanut. Based on 555 open food challenges in 
      467 children (median age 3.0 yr) we defined food-specific SPT weal diameters that 
      were '100% diagnostic' for allergy to cow milk (>or=8 mm), egg (>or=7 mm) and 
      peanut (>or=8 mm). In children < 2 yr of age, the corresponding weal diameters 
      were >or=6 mm, >or=5 mm and >or=4 mm, respectively. These SPT cut-off levels were 
      prospectively validated in 90 consecutive children <or=2 yr with challenge-proven 
      food allergy. In young infants under 6 months of age who have not previously been 
      exposed to a particular food item, the SPT were often negative or below the 
      diagnostic cut-off but reached the diagnostic cut-off at the time of challenge in 
      the second year of life. We assessed the diagnostic agreement between 
      food-specific immunoglobulin E (IgE) antibody levels and SPT in a cohort of 820 
      infants and children under 2 yr of age (median age 13.1 months) with suspected 
      allergy to cow milk, egg or peanut. When applying published 95%-positive 
      predictive CAP values, the diagnostic accuracy of SPT and IgE antibody levels was 
      similar for cow milk, but SPT was more sensitive in diagnosing allergy to egg (p 
      < 0.0001) and peanut (p < 0.0001). Further studies are required to define 
      age-specific diagnostic IgE antibody and SPT cut-off levels use in infants under 
      2 yr of age with suspected food allergies.
FAU - Hill, David J
AU  - Hill DJ
AD  - Department of Allergy, Royal Children's Hospital, Flemington Road, Parkville, 
      Victoria 3052, Australia. allergy.clinic@rch.org.au
FAU - Heine, Ralf G
AU  - Heine RG
FAU - Hosking, Clifford S
AU  - Hosking CS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Food Hypersensitivity/*diagnosis
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Radioallergosorbent Test
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - *Skin Tests
EDAT- 2004/10/16 09:00
MHDA- 2005/02/03 09:00
CRDT- 2004/10/16 09:00
PHST- 2004/10/16 09:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/10/16 09:00 [entrez]
AID - PAI188 [pii]
AID - 10.1111/j.1399-3038.2004.00188.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2004 Oct;15(5):435-41. doi: 
      10.1111/j.1399-3038.2004.00188.x.