PMID- 15482521
OWN - NLM
STAT- MEDLINE
DCOM- 20050201
LR  - 20151119
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 15
IP  - 5
DP  - 2004 Oct
TI  - General paediatricians and the case of resolving peanut allergy.
PG  - 449-53
AB  - Children with peanut allergy are almost always advised to avoid nuts for life. 
      There have been recent reports from academic centres that in some cases the 
      allergy might resolve and thus these dietary restrictions can be lifted. To 
      evaluate resolution of peanut allergy in a selected group of children in a 
      general paediatric setting. Children 4-16 yr old with a clear history of an 
      allergic reaction to peanuts who had not had any reaction in the previous 2 yr 
      were eligible. Specific immunoglobulin E (IgE) or skin prick test (SPT) at the 
      time of diagnosis was sought. A SPT and specific IgE was then done and if this 
      was <or= 8 mm and <or= 17.5 kU[A]/l respectively, a double-blind 
      placebo-controlled food challenge was undertaken. A negative challenge consisted 
      of tolerance to a cumulative dose of 15.8 g peanuts followed by an open 
      challenge. From the 82 case notes reviewed 54 children were eligible to 
      participate. Twenty-nine agreed to participate and underwent SPT (29) and 
      specific IgE (28). Of these children eight were eligible for food challenge. Four 
      challenges were negative and four positive. Peanut allergy may resolve in 
      approximately 15% of selected children attending an allergy clinic run by general 
      paediatricians in a district general hospital. Food challenge constitutes the 
      appropriate way of removing the burden that comes with a diagnosis of peanut 
      allergy and enables dietary restriction to cease.
FAU - Rangaraj, Satyapal
AU  - Rangaraj S
AD  - Department of Child Health, Llandough Hospital, Penarth, Cardiff, UK.
FAU - Ramanathan, Veena
AU  - Ramanathan V
FAU - Tuthill, David P
AU  - Tuthill DP
FAU - Spear, Elizabeth
AU  - Spear E
FAU - Hourihane, Jonathan O'b
AU  - Hourihane JO
FAU - Alfaham, Mazin
AU  - Alfaham M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Arachis/*adverse effects
MH  - Child
MH  - Child, Preschool
MH  - *Family Practice
MH  - Humans
MH  - Immune Tolerance/physiology
MH  - Immunoglobulin E/blood
MH  - Peanut Hypersensitivity/*diagnosis
MH  - *Pediatrics
MH  - Physicians
MH  - Remission, Spontaneous
MH  - Risk Factors
MH  - Skin Tests
EDAT- 2004/10/16 09:00
MHDA- 2005/02/03 09:00
CRDT- 2004/10/16 09:00
PHST- 2004/10/16 09:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/10/16 09:00 [entrez]
AID - PAI174 [pii]
AID - 10.1111/j.1399-3038.2004.00174.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2004 Oct;15(5):449-53. doi: 
      10.1111/j.1399-3038.2004.00174.x.