PMID- 15483127
OWN - NLM
STAT- MEDLINE
DCOM- 20050112
LR  - 20200225
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 24
IP  - 41
DP  - 2004 Oct 13
TI  - Differential requirements for semaphorin 3F and Slit-1 in axonal targeting, 
      fasciculation, and segregation of olfactory sensory neuron projections.
PG  - 9087-96
AB  - The formation of precise stereotypic connections in sensory systems is critical 
      for defining accurate internal representations of the external world; however, 
      the molecular mechanisms underlying the formation of sensory maps are poorly 
      understood. Here, we examine the roles of two structurally unrelated repulsive 
      guidance cues, semaphorin 3F (Sema3F) and Slit-1, in olfactory sensory axon 
      fasciculation, targeting, and segregation. Using sema3F-/- mice, we show that 
      Sema3F is critical for vomeronasal sensory neuron axonal fasciculation and for 
      segregation of these sensory afferents from the main olfactory system; however, 
      Sema3F plays only a minor role in targeting of apical vomeronasal neuron axons to 
      the anterior accessory olfactory bulb (AOB). In addition, we show that Sema3F is 
      required for lamina-specific targeting of olfactory sensory axons within the main 
      olfactory system. In contrast to Sema3F, Slit-1 is dispensable for fasciculation 
      of basal vomeronasal neuron axons but is critical for targeting these axons to 
      the posterior AOB. These results reveal discrete and complementary roles for 
      secreted semaphorins and slits in axonal targeting, fasciculation, and 
      segregation of olfactory sensory neuron projections.
FAU - Cloutier, Jean-Francois
AU  - Cloutier JF
AD  - Department of Neuroscience, The Johns Hopkins University School of Medicine, 
      Baltimore, Maryland 21205, USA.
FAU - Sahay, Amar
AU  - Sahay A
FAU - Chang, Ernie C
AU  - Chang EC
FAU - Tessier-Lavigne, Marc
AU  - Tessier-Lavigne M
FAU - Dulac, Catherine
AU  - Dulac C
FAU - Kolodkin, Alex L
AU  - Kolodkin AL
FAU - Ginty, David D
AU  - Ginty DD
LA  - eng
GR  - R01 DC003903/DC/NIDCD NIH HHS/United States
GR  - R01 MH059199/MH/NIMH NIH HHS/United States
GR  - R01DC003903-06/DC/NIDCD NIH HHS/United States
GR  - R01MH59199/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Sema3f protein, mouse)
RN  - 0 (Slit1 protein, mouse)
RN  - EC 3.6.5.1 (GTP-Binding Protein alpha Subunits, Gi-Go)
SB  - IM
MH  - Animals
MH  - Axons/*physiology
MH  - GTP-Binding Protein alpha Subunits, Gi-Go/biosynthesis
MH  - Membrane Proteins/genetics/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Nerve Tissue Proteins/genetics/*physiology
MH  - Neurons, Afferent/cytology/*physiology
MH  - Olfactory Bulb/cytology/physiology
MH  - Olfactory Pathways/cytology/growth & development/*physiology
MH  - Signal Transduction/physiology
MH  - Vomeronasal Organ/*innervation
PMC - PMC6730055
EDAT- 2004/10/16 09:00
MHDA- 2005/01/13 09:00
PMCR- 2005/04/13
CRDT- 2004/10/16 09:00
PHST- 2004/10/16 09:00 [pubmed]
PHST- 2005/01/13 09:00 [medline]
PHST- 2004/10/16 09:00 [entrez]
PHST- 2005/04/13 00:00 [pmc-release]
AID - 24/41/9087 [pii]
AID - 10.1523/JNEUROSCI.2786-04.2004 [doi]
PST - ppublish
SO  - J Neurosci. 2004 Oct 13;24(41):9087-96. doi: 10.1523/JNEUROSCI.2786-04.2004.